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Safener

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By Targets:	Acetolactate Synthase (ALS) (2) Autophagy (1) Caspase (1) COX (1) Cytochrome P450 (2) Environmental Pollutants (5) Estrogen Receptor/ERR (2) FXR (2) Glutathione S-transferase (5) Herbicide (14) Interleukin Related (1) NO Synthase (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) PERK (1) Phytohormone (1) Pregnane X Receptor (PXR) (2) Reactive Oxygen Species (ROS) (1) Reference Standards (5) SOD (2) TNF Receptor (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (1)

By Targets:

Acetolactate Synthase (ALS) (2)

Autophagy (1)

Caspase (1)

COX (1)

Cytochrome P450 (2)

Environmental Pollutants (5)

Estrogen Receptor/ERR (2)

FXR (2)

Glutathione S-transferase (5)

Herbicide (14)

Interleukin Related (1)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (1)

PERK (1)

Phytohormone (1)

Pregnane X Receptor (PXR) (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (5)

SOD (2)

TNF Receptor (1)

By Research Areas:

Cancer (2)

Inflammation/Immunology (1)

Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W923189

Neral	Interleukin Related COX TNF Receptor NOD-like Receptor (NLR) NO Synthase PERK p38 MAPK Reactive Oxygen Species (ROS) Caspase Autophagy Herbicide	Inflammation/Immunology Cancer
Neral is a plant-derived anti-inflammatory, antioxidant and anticancer agent. Neral inhibits the phosphorylation of ERK1/2, p38 MAPK and IκB in macrophages induced by LPS (HY-D1056), suppresses the secretion of TNF-α and IL-6, as well as the expression of pro-IL-1β, iNOS and COX-2 in cells, and reduces the production of ROS in cells. Neral inhibits the activation of the NLRP3 inflammasome, and decreases the activation of caspase-1 and the secretion of IL-1β in mouse macrophages. Neral induces autophagy, and exhibits antiproliferative activity both in in vitro breast cancer cell models and mouse xenograft models. Neral regulates brassinosteroid, jasmonic acid and ethylene signaling pathways, and induces the expression of AP2/ERF-ERF and bHLH family genes in rice roots. Neral acts as a herbicide safener, alleviates the damage induced by Fenoxaprop-P-ethyl (HY-B2013), and promotes the elongation of rice roots. Neral can be used in research related to breast cancer, inflammatory and immune system diseases, and herbicide safeners .

HY-B2024

Cloquintocet-mexyl	Environmental Pollutants Herbicide	Others
Cloquintocet-mexyl is a herbicide safener. Cloquintocet-mexyl promotes the expression of genes related to chlorophyll synthesis (such as GTR and PPO) and chlorophyll-binding protein genes (CBP), increases the chlorophyll content, thereby promoting photosynthesis and reducing oxidative stress. Cloquintocet-mexyl improves wheat tolerance to Fomesafen (HY-B2010) .

HY-136376

Mefenpyr-diethyl	Environmental Pollutants Herbicide	Others
Mefenpyr-diethyl is a pyrazoline-type herbicide safener that functions to enhance lipid biosynthesis. Mefenpyr-diethyl effectively prevents herbicide-induced phytotoxic damage caused by herbicides such as fenoxaprop-p-ethyl (HY-B2013) and mesosulfuron-methyl (HY-126987) by protecting cereal crops including wheat. Mefenpyr-diethyl significantly increases lipid content in wheat either when applied alone or in combination with the herbicide fenoxaprop-p-ethyl. The mechanism of action of Mefenpyr-diethyl does not involve the induction of glutathione S-transferase (GST) activity in wheat .

HY-170920

*Herbicide safener-4*	Cytochrome P450 SOD Glutathione S-transferase Acetolactate Synthase (ALS)	Others
Herbicide safener-4 (Compound I-15) is a Herbicide safener, improving the herbicide resistance of crops without reducing the herbicidal effect on targeted weed species. Herbicide safener-4 competitively binds to the ALS active site with Mesosulfuron-methyl (HY-126987). Herbicide safener-4 enhances GSH (HY-D0187), GST, CYP450, POD, SOD and ALS activity in plants .

HY-W020788

Benoxacor CGA 154281	Environmental Pollutants Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Metabolic Disease Cancer
Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-130361

Isoxadifen-ethyl	Environmental Pollutants Herbicide	Others
Isoxadifen-ethyl is a widely used herbicide safener in rice which can decrease the phytotoxicity caused by fenoxaprop-P-ethyl .

HY-W775385

Metcamifen	Herbicide	Others
Metcamifen is a herbicide safener that can protect rice from Clodinafop-propargyl (HY-136380) .

HY-W681867

Fluxofenim CGA-133205	Herbicide Glutathione S-transferase	Others
Fluxofenim (CGA-133205) is a herbicide safener, with activity against Pyroxasulfone (HY-136633) and Metolachlor (HY-B1871). Fluxofenim enhances the activity of needle glutathione S-transferase (GST) towards the substrate 1-chloro-2,4-dinitrobenzene (CDNB) .

HY-W014522

Dichlormid 1 Publications Verification	Environmental Pollutants Herbicide	Others
Dichlormid is a herbicide safener. Dichlormid up-regulates expression of ZmGST27 and ZmMRP1 and increases ZmGT1 .

HY-158245

*Herbicide safener-2*	Acetolactate Synthase (ALS)	Others
Herbicide safener-2 (Compound III-7) is a herbicide safener with the same pharmacokinetic profile as the safener mefenpyr-diethyl (HY-136376). Herbicide safener-2 competitively binds to the acetolactate synthase (ALS) active site with mesosulfuron-methyl (HY-126987). Herbicide safener-2 protects crops against herbicide injury .

HY-158981

*Herbicide safener-3*	Herbicide	Others
Herbicide safener-3 is a compound that increases the selectivity of herbicides. Herbicide safener-3 is often used together with herbicides, particularly those that can be harmful to crops. Herbicide safener-3 reduces the negative effects of herbicide on the crop by regulating metabolic differences between the crop and the weed while still allowing the herbicide to be effective on the weed. Herbicide safener-3 can be used in research that improves herbicide application effectiveness and crop safety .

HY-W020788R

Benoxacor (Standard) CGA 154281 (Standard)	Reference Standards Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Others
Benoxacor (Standard) is the analytical standard of Benoxacor. This product is intended for research and analytical applications. Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-181407

*Herbicide safener-5*	Herbicide Glutathione S-transferase Cytochrome P450 SOD	Others
Herbicide safener-5 is a herbicide (Herbicide) safener. Herbicide safener-5 promotes plant growth recovery, enhances the activities of detoxifying enzymes (ALS, GST, CYP450, POD), and reduces SOD activity. Herbicide safener-5 is applicable to herbicide-related research .

HY-W014522R

Dichlormid (Standard)	Herbicide Reference Standards	Others
Dichlormid (Standard) is the analytical standard of Dichlormid. This product is intended for research and analytical applications. Dichlormid is a herbicide safener. Dichlormid up-regulates expression of ZmGST27 and ZmMRP1 and increases ZmGT1 .

HY-153727

*Herbicide safener-1*	Phytohormone	Others
Herbicide safener-1 (II-Q001) is a crop protection and safety agent. Herbicide safener-1 can protect crops from the damage caused by pesticides (such as herbicides and fungicides) .

HY-136376R

Mefenpyr-diethyl (Standard)	Herbicide Reference Standards	Others
Mefenpyr-diethyl (Standard) is the analytical standard of Mefenpyr-diethyl. This product is intended for research and analytical applications. Mefenpyr-diethyl is an herbicide safener. Mefenpyr-diethyl enhances plant tolerance to herbicides by inducing the expression of antioxidant enzymes such as GST. Mefenpyr-diethyl protects crops against herbicide injury .

HY-130361R

Isoxadifen-ethyl (Standard)	Herbicide Reference Standards	Others
Isoxadifen-ethyl (Standard) is the analytical standard of Isoxadifen-ethyl. This product is intended for research and analytical applications. Isoxadifen-ethyl is a widely used herbicide safener in rice which can decrease the phytotoxicity caused by fenoxaprop-P-ethyl .

HY-116690

Daimuron	Herbicide	Others
Daimuron is a herbicide safener. Daimuron has a protective effect against the inhibition of seed root elongation by chloroacetanilide herbicides .

HY-116690R

Daimuron (Standard)	Herbicide Reference Standards	Others
Daimuron (Standard) is the analytical standard of Daimuron. This product is intended for research and analytical applications. Daimuron is a herbicide safener. Daimuron has a protective effect against the inhibition of seed root elongation by chloroacetanilide herbicides .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Safener

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