Isoxadifen-ethyl
Based on 1 Customer Validation
Isoxadifen-ethyl is a Herbicide safener that reduces herbicide toxicity to crops. Isoxadifen-ethyl enhances maize tolerance to Nicosulfuron (HY-B1876) by regulating detoxification gene expression; it reduces the phytotoxicity and damage induced by Cyhalofop-butyl (HY-B0861) in rice. Isoxadifen-ethyl is applicable to herbicide-related research.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 163520-33-0
- Formula: C18H17NO3
- Molecular Weight:295.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Isoxadifen-ethyl (33 mg/L; 24 h) significantly upregulates the expression levels of ZmGSTIV, ZmGST6, ZmGST31 and ZmMRP1 in the leaves of maize cultivar Zhenghuangnuo 2, while downregulating the expression of ZmGSTIII and ZmGST27[1].
Isoxadifen-ethyl (33 mg/L; 24 h) significantly upregulates the expression levels of ZmGSTIV, ZmGST6, ZmGST31 and ZmMRP1 in leaves of maize variety Zhengdan 958, while downregulating the expression levels of ZmGSTIII, ZmGST27 and ZmGT1[1].
Isoxadifen-ethyl (33 mg/L; 4-48 h) significantly upregulates the expression levels of ZmGSTIV, ZmGST6, ZmGST31 and ZmMRP1 in the leaves of maize varieties Zhenghuangnuo 2 and Zhengdan 958[1].
Isoxadifen-ethyl acts as a broad-spectrum, multi-crop herbicide safener that protects maize and rice from phytotoxicity induced by Foramsulfuron (HY-W422402), Mesotrione (HY-12853), Isoxaflutole (HY-116139) and fenoxaprop-P-ethyl[2].
Isoxadifen-ethyl (compound 1) (50-100 μM; 5 d) effectively alleviates the phytotoxicity of Cyhalofop-butyl (HY-B0861) to cultivated rice seedlings in agar-based assays, with a plant height recovery rate of 95.86% and a fresh weight recovery rate of 89.87%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 163520-33-0
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Appearance Solid
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Molecular Weight 295.34
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Formula C18H17NO3
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Color White to light yellow
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SMILES
O=C(C1=NOC(C2=CC=CC=C2)(C3=CC=CC=C3)C1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (338.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Sun L, et al. The expression of detoxification genes in two maize cultivars by interaction of isoxadifen-ethyl and nicosulfuron. Plant physiology and biochemistry : PPB. 2018 Aug;129:101-108. [Content Brief]
[2]. Jia L, et al. Research Progress in the Design and Synthesis of Herbicide Safeners: A Review. Journal of agricultural and food chemistry. 2022 May 11;70(18):5499-5515. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3859 mL | 16.9296 mL | 33.8593 mL | 84.6482 mL |
| 5 mM | 0.6772 mL | 3.3859 mL | 6.7719 mL | 16.9296 mL | |
| 10 mM | 0.3386 mL | 1.6930 mL | 3.3859 mL | 8.4648 mL | |
| 15 mM | 0.2257 mL | 1.1286 mL | 2.2573 mL | 5.6432 mL | |
| 20 mM | 0.1693 mL | 0.8465 mL | 1.6930 mL | 4.2324 mL | |
| 25 mM | 0.1354 mL | 0.6772 mL | 1.3544 mL | 3.3859 mL | |
| 30 mM | 0.1129 mL | 0.5643 mL | 1.1286 mL | 2.8216 mL | |
| 40 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1162 mL | |
| 50 mM | 0.0677 mL | 0.3386 mL | 0.6772 mL | 1.6930 mL | |
| 60 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.4108 mL | |
| 80 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0581 mL | |
| 100 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.8465 mL |
Isoxadifen-ethyl Related Classifications
HY-130361 Related Classifications
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