Herbicide safener-4

Herbicide safener-4 (I-15) increases GSH content in Xinong 3517 wheat exposed to Mesosulfuron-methyl (HY-126987), with values of 29.3 ng/L in roots and 15.9 ng/L in shoots^[1].
Herbicide safener-4 significantly enhances CYP450 activity in Xinong 3517 wheat exposed to mesosulfuron-methyl, with values of 753.6 IU/L in roots and 312.1 IU/L in shoots^[1].
Herbicide safener-4 strongly enhances POD activity in Xinong 3517 wheat exposed to mesosulfuron-methyl, with values of 7.3 mU/L in roots and 4.7 mU/L in shoots^[1].
Herbicide safener-4 reduces elevated SOD activity in Xinong 3517 wheat exposed to mesosulfuron-methyl, with values of 1101.9 U/L in roots and 526.2 U/L in shoots^[1].
Herbicide safener-4 effectively restores ALS activity in Xinong 3517 wheat exposed to mesosulfuron-methyl, with values of 333.7 IU/L in roots and 296.2 IU/L in shoots^[1].
Herbicide safener-4 binds to the active site of Arabidopsis thaliana ALS with an interaction energy of 44.43 kcal/mol, forming multiple stabilizing interactions that allow it to competitively block mesosulfuron-methyl binding^[1].
Herbicide safener-4 forms a stable complex with Arabidopsis thaliana ALS over a 100 ns MD simulation, with consistent RMSD values confirming sustained binding to the enzyme's active site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.