98730-04-2
Chemical Structure
Benoxacor
Synonym(s): CGA 154281
- CAS No.: 98730-04-2
- Formula:C11H11Cl2NO2
- Molecular Weight:260.12
IUPAC Name: 2,2-dichloro-1-(3-methyl-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one
InChIKey: PFJJMJDEVDLPNE-UHFFFAOYSA-N
SMILES: ClC(Cl)C(N1C(C)COC2=CC=CC=C21)=O
Biological Activity:
Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity[1][2][3].
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Benoxacor | 99.39% | Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity. |
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Benoxacor (Standard) | ≥98% | Benoxacor (Standard) is the analytical standard of Benoxacor. This product is intended for research and analytical applications. Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity. | ||||||||||||||||||||
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- [1]. Simonsen D, et al. The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicol Sci. 2022;186(1):102-117. [Content Brief]
- [2]. Zhang W, et al. Benoxacor caused developmental and cardiac toxicity in zebrafish larvae. Ecotoxicol Environ Saf. 2021;224:112696. [Content Brief]
- [3]. Miller K D, Irzyk G P, FuERsT E P. Benoxacor treatment increases glutathione S-transferase activity in suspension cultures of Zea mays[J]. Pesticide biochemistry and physiology, 1994, 48(2): 123-134.
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