Cloquintocet-mexyl
Based on 1 Customer Validation
Cloquintocet-mexyl is a herbicide safener. Cloquintocet-mexyl promotes the expression of genes related to chlorophyll synthesis (such as GTR and PPO) and chlorophyll-binding protein genes (CBP), increases the chlorophyll content, thereby promoting photosynthesis and reducing oxidative stress. Cloquintocet-mexyl improves wheat tolerance to Fomesafen (HY-B2010).
For research use only. We do not sell to patients.
- Purity: 99.33%
- CAS No.: 99607-70-2
- Formula: C18H22ClNO3
- Molecular Weight:335.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Cloquintocet-mexyl (4-32 mg/L; 12 h) significantly increases the plant height and fresh weight of Bainong207 wheat seedlings under Fomesafen (HY-B2010) stress, alleviating Fomesafen injury[1].
Cloquintocet-mexyl (10 mg/L; 8 h) significantly enhances GST and GPOX activities in 7-day-old wheat seedlings within 8 h of treatment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 99607-70-2
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Appearance Solid
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Molecular Weight 335.83
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Formula C18H22ClNO3
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Color White to off-white
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SMILES
O=C(OC(C)CCCCC)COC1=C2N=CC=CC2=C(Cl)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (297.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (762 KB)
- English - EN (762 KB)
- Français - FR (762 KB)
- Deutsch - DE (762 KB)
- Norwegian - NO (762 KB)
- Español - ES (762 KB)
- Swedish - SV (762 KB)
- Italian - IT (762 KB)
- Korean - KR (762 KB)
- Portuguese - PT (762 KB)
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Handling Instructions (2659 KB)
References
[1]. Li D, et al. Seed pretreatment with cloquintocet-mexyl protects wheat seedlings from fomesafen injury by promoting photosynthesis and decreasing oxidative stress. Pest Manag Sci. 2025 Jun;81(6):2812-2822. [Content Brief]
[2]. Taylor VL, et al. Protective responses induced by herbicide safeners in wheat. Environ Exp Bot. 2013 Apr;88(C):93-99. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9777 mL | 14.8885 mL | 29.7770 mL | 74.4424 mL |
| 5 mM | 0.5955 mL | 2.9777 mL | 5.9554 mL | 14.8885 mL | |
| 10 mM | 0.2978 mL | 1.4888 mL | 2.9777 mL | 7.4442 mL | |
| 15 mM | 0.1985 mL | 0.9926 mL | 1.9851 mL | 4.9628 mL | |
| 20 mM | 0.1489 mL | 0.7444 mL | 1.4888 mL | 3.7221 mL | |
| 25 mM | 0.1191 mL | 0.5955 mL | 1.1911 mL | 2.9777 mL | |
| 30 mM | 0.0993 mL | 0.4963 mL | 0.9926 mL | 2.4814 mL | |
| 40 mM | 0.0744 mL | 0.3722 mL | 0.7444 mL | 1.8611 mL | |
| 50 mM | 0.0596 mL | 0.2978 mL | 0.5955 mL | 1.4888 mL | |
| 60 mM | 0.0496 mL | 0.2481 mL | 0.4963 mL | 1.2407 mL | |
| 80 mM | 0.0372 mL | 0.1861 mL | 0.3722 mL | 0.9305 mL | |
| 100 mM | 0.0298 mL | 0.1489 mL | 0.2978 mL | 0.7444 mL |
Cloquintocet-mexyl Related Classifications
HY-B2024 Related Classifications
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