Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Shikonin
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Shikonin" in MCE Product Catalog:
72
72 Publications Verification
Synonyms: C.I. 75535; Isoarnebin 4
1
Category:
Quinones other families Phenols Polyphenols Plants Disease Research Fields Naphthalene Quinones Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-N2188
CAS No.: 69091-17-4
Category:
Plants Boraginaceae Naphthalene Quinones Quinones other families Phenols Polyphenols Disease Research Fields Inflammation/Immunology Arnebia euchroma (Royle) Johnst.
Target:
Cat. No.: HY-158208
CAS No.: 2209036-28-0
Target:
Research Areas:
PMMB276, a Shikonin (HY-N0822) derivative, is a potent Tubb3 inhibitor. PMMB276 inhibits microtubule polymerization, induces G2/M cell cycle arrest and apoptosis in TNBC cells through the Cdc20/AKT2/Bcl-2 signaling axis. PMMB276 suppresses MDA-MB-231 tumor growth in mice without causing significant toxicity. PMMB276 can be used for the study of triple-negative breast cancer (TNBC) .
Cat. No.: HY-N2592
CAS No.: 52438-12-7
Category:
Quinones Phenols Polyphenols Plants Lithospermum canescens Lehm. Disease Research Fields Inflammation/Immunology Boraginaceae Naphthalene Quinones
Target:
Cat. No.: HY-124427
CAS No.: 83415-79-6
Category:
Quinones Plants Lithospermum erythrorhizon Sieb. et Zucc. Boraginaceae Naphthalene Quinones
Target:
Cat. No.: HY-N3012
CAS No.: 52387-14-1
Target:
Research Areas:
Isovalerylshikonin (IVS) is a shikonin pigment is identified in the root epidermis of Echium italicum L .
Cat. No.: HY-174254
CAS No.: 3099809-16-9
AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells .
Cat. No.: HY-N8725
CAS No.: 52387-15-2
Category:
Quinones Plants Lithospermum erythrorhizon Sieb. et Zucc. Boraginaceae Naphthalene Quinones
Target:
Cat. No.: HY-149275
CAS No.: 3041957-90-5
PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2/PDK1. PKM2/PDK1-IN-1 inhibits the proliferation of NSCLC cells, and induces apoptosis. PKM2/PDK1-IN-1 induces intercellular ROS production, and regulates the apoptotic proteins, to involves in mitochondrial and death receptor pathway .
Cat. No.: HY-N15277
CAS No.: 104056-81-7
Target:
Cat. No.: HY-184243
CAS No.: 3099924-90-7
Research Areas:
ISR/ROS-activator-1 is a naphthoquinone compound derived from Shikonin (HY-N0822), and also dual activator of the ISR/ROS pathway. ISR/ROS-activator-1 induces Apoptosis and Ferroptosis. ISR/ROS-activator-1 selectively inhibits gastric cancer. ISR/ROS-activator-1 is applicable to gastric cancer-related research .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
