8 Results for "

Sortase Inhibitors

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "Sortase Inhibitors" in MCE Product Catalog:

1
Rhodionin
Rhodionin
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1 Cited Publications
Cat. No.: HY-N0241
CAS No.: 85571-15-9
Category:  

Flavonols Crassulaceae Metabolic Disease Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Flavonoids Rhodiola rosea Linn. Phenols Polyphenols Disease Research Fields

Target:  

Free Radical Scavengers Cholinesterase (ChE) Lipase Bacterial Cytochrome P450

Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC50=0.761 μM), AChE (IC50=2.43-57.5 μM), and DPPH free radicals (IC50=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) .
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Hibifolin
Hibifolin
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Cat. No.: HY-N7368
CAS No.: 55366-56-8
Category:  

Flavonols other families Flavonoids Neurological Disease Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Adenosine Deaminase Bacterial Caspase

Hibifolin is a flavonol glycoside that can be isolated from Helicteres isora. Hibifolin is an inhibitor of adenosine deaminase (ADA) (Ki = 49.92 μM). Hibifolin protects neurons against β-amyloid-induced neurotoxicity. Hibifolin possesses a potent protective activity against cell death induced by aggregated Aβ. Hibifolin can abolish Aβ-induced caspase-3 and caspase-7 activation. Hibifolin induces Akt phosphorylation in cortical neurons. Hibifolin is also a natural sortase A (SrtA) inhibitor (IC50 = 31.2 μM) through direct binding to SrtA protein. Hibifolin attenuates the pathogenic behavior of Staphylococcus aureus including adhesion, invasion, and biofilm formation. Hibifolin improves the survival of pneumonia induced by Staphylococcus aureus in mouse model and alleviates pathological damage. Hibifolin shows a synergistic antibacterial effect with Cefotaxime (HY-A0088A) .
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SrtA-IN-1
SrtA-IN-1
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Cat. No.: HY-173219
Target:  

Bacterial

Research Areas:  

Infection

SrtA-IN-1 (Compound T10) is an inhibitor of Streptococcus pyogenes sortase A (SpSrtA), with an IC50 value of 0.7 μM. SrtA-IN-1 can be used in the research of the anti-infection field .
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SrtA-IN-2
SrtA-IN-2
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Cat. No.: HY-161124
Target:  

Bacterial

Research Areas:  

Infection

SrtA-IN-2 (compound Y40), a ML346 (HY-18669) analog, is a Sortase A (SrtA) inhibitor. SrtA-IN-2 shows inhibitory activity on Staphylococcus aureus SrtA and shows inhibitory effects on biofilm formation. SrtA-IN-2 is an antivirulence agent against S. aureus infections .
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Hibifolin (Standard)
Hibifolin (Standard)
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Cat. No.: HY-N7368R
CAS No.: 55366-56-8
Category:  

Flavonols other families Flavonoids Phenols Polyphenols Plants

Target:  

Reference Standards Adenosine Deaminase Bacterial Caspase

Hibifolin (Standard) is the analytical standard of Hibifolin. This product is intended for research and analytical applications. Hibifolin is a flavonol glycoside that can be isolated from Helicteres isora. Hibifolin is an inhibitor of adenosine deaminase (ADA) (Ki = 49.92 μM). Hibifolin protects neurons against β-amyloid-induced neurotoxicity. Hibifolin possesses a potent protective activity against cell death induced by aggregated Aβ. Hibifolin can abolish Aβ-induced caspase-3 and caspase-7 activation. Hibifolin induces Akt phosphorylation in cortical neurons. Hibifolin is also a natural sortase A (SrtA) inhibitor (IC50 = 31.2 μM) through direct binding to SrtA protein. Hibifolin attenuates the pathogenic behavior of Staphylococcus aureus including adhesion, invasion, and biofilm formation. Hibifolin improves the survival of pneumonia induced by Staphylococcus aureus in mouse model and alleviates pathological damage. Hibifolin shows a synergistic antibacterial effect with Cefotaxime (HY-A0088A) .
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(7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside
(7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside
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Cat. No.: HY-N17584
CAS No.: 126371-34-4
Category:  

Phenols Plants Compositae Achillea millefolium L.

Target:  

Bacterial

(7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside (compound 1) is a lignan found in the dried roots of Pulsatilla koreana and Sortase A inhibitor with an IC50 of 67.7 μM against Streptococcus mutans OMZ65 Sortase A. (7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside can be used for the research of dental caries .
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(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside
(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside
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Cat. No.: HY-N17582
CAS No.: 1526987-82-5
Category:  

Ranunculaceae Phenols Plants Pulsatilla cernua (Thunb.) Bercht. et Opiz.

Target:  

Bacterial

(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside is a Streptococcus mutans Sortase A inhibitor with an IC50 of 37.3 μM. (7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside inhibits transpeptidase activity linked to Gram-positive bacterial surface protein anchoring. (7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside can be used for the research of dental caries .
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Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside
Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside
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Cat. No.: HY-N20632
CAS No.: 942503-47-1
Category:  

Monophenols Leguminosae Sophora japonica (L.) Schott Phenols Plants

Target:  

Bacterial

Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside is a sortase A inhibitor of Streptococcus mutans, with an IC50 value of 94.3 μM. Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside inhibits saliva-induced aggregation of Streptococcus mutans. Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside can be used in caries-related research .
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