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Stereochemistry

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By Targets:	Amino Acid Derivatives (1) Bacterial (1) Biochemical Assay Reagents (5) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (1) GABA Receptor (1) Histone Demethylase (1) Histone Methyltransferase (1) iGluR (1) Monoamine Oxidase (1) Oligopeptide Cotransporter (1) Opioid Receptor (1) Polo-like Kinase (PLK) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (5)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1018A

Phenelzine sulfate 5+ Cited Publications	Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-137824

4-Methylumbelliferyl-β-D-xylopyranoside 4-Methylumbelliferyl-β-D-xyloside	Biochemical Assay Reagents	Others
4-Methylumbelliferyl-β-D-xylopyranoside (4-Methylumbelliferyl-β-D-xyloside) is an enzymatically hydrolyzable β-D-xylopyranoside substrate. The enzymatic hydrolysis of 4-Methylumbelliferyl-β-D-xylopyranoside is mediated by the stereochemistry-retaining β-D-xylosidase GSXynB2 via a two-step catalytic process (xylosylation followed by dexylosidation). 4-Methylumbelliferyl-β-D-xylopyranoside serves as a substrate for the β-xylosidase of Trichoderma reesei QM 9414, and its enzymatic hydrolysis process is limited by the dexylosidation step.

HY-126584

H-Val-Val-OH Val-Val	Drug Intermediate Oligopeptide Cotransporter	Others
H-Val-Val-OH (Val-Val) is a stereochemistry-dependent substrate and inhibitor of apical oligopeptide transporters. H-Val-Val-OH undergoes apical intracellular accumulation in human intestinal cells via carrier-mediated transport, and inhibits the uptake of Cephalexin (HY-B0200) through interaction with transporters. Substitution of L-valine with D-valine in H-Val-Val-OH abolishes its binding ability to apical oligopeptide transporters .

HY-W010394

Methyl 3-oxopentanoate	Biochemical Assay Reagents	Others
Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.

HY-120949

(1R,2R)-U-50488 hydrochloride	Opioid Receptor	Neurological Disease
(1R,2R)-U-50488 hydrochloride is the absolute stereochemistry of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a selective κ opioid receptor (KOR) agonist .

HY-175402

(S)-5-Hydroxyequol	Drug Isomer	Infection Inflammation/Immunology
(S)-5-Hydroxyequol is a (S)-stereochemistry of 5-Hydroxyequol. (S)-5-Hydroxyequol can be used for research on oxidative damage, fungal infections, inflammation, and immunosuppression .

HY-W039854

1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose, 96% 1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranose, 96%	Biochemical Assay Reagents	Others
1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose, 96% (1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranose, 96%) can be used in glycobiology research to study glycosylation mechanisms, glycosidic bond formation, and stereochemistry.

HY-W035375

*Mephedrone metabolite hydrochloride ((±)-ephedrine stereochemistry)*	Drug Metabolite	Neurological Disease
Mephedrone metabolite hydrochloride ((±)-ephedrine stereochemistry) is a metabolite of Mephedrone.

HY-113801

N-(3-Oxooctanoyl)-DL-homoserine lactone (Rac)-3-oxo-C8-HSL	Endogenous Metabolite	Metabolic Disease
N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .

HY-134775A

PLK4-IN-3	Polo-like Kinase (PLK)	Cancer
PLK4-IN-3 is a less active absolute stereochemistry of PLK4-IN-1. PLK4-IN-1 is a PLK4 inhibitor, with an IC₅₀ of 0.65 μM .

HY-W144704B

(3RS,7R,11R)-Dihydrophytol	Drug Intermediate	Others
(3RS, 7R, 11R)-Dihydrophytol is the hydrogenation intermediate in the synthesis of Phytanic acid (HY-113067) from Phytol (HY-N3075) .

HY-N12962

11S(12R)-EET	Others	Others
11S(12R)-EET is a dominant enantiomer of epoxytrienoic acid (EET) that is metabolized at a higher rate in rat organs. It shows enantiomeric-dependent reaction selectivity in hydration, especially in the case of 11,12-EET, where water addition is non-regioselective, while in 8,9-EET, water addition occurs mainly at the C9 position. In addition, 11S(12R)-EET generates diol products with specific stereochemistry through enzymatic hydration reactions, which are affected by the selective recognition of epoxidases, reaction conversion rates, and substrate binding parameters .

HY-137938

Radicinol	Bacterial	Infection
Radicinol is a metabolite of cochliobolus lunata, and absolute stereochemistry of radicinin .

HY-160983

PHYLPA-8	DNA/RNA Synthesis	Cancer
PHYLPA-8 is an inhibitor for DNA polymerase-α, which exhibits weak inhibitory activity for the stereochemistry of the fatty acid moiety and the cyclic phosphate .

HY-117542

D595	Histone Methyltransferase	Neurological Disease
D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .

HY-N15259

3'R-HBHL	Biochemical Assay Reagents	Others
3'R-HBHL is a reference compound used for determining the stereochemistry of small bacteriocins .

HY-W720429

2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine	Drug Metabolite	Metabolic Disease
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is a metabolite in the biosynthesis pathway (purine metabolism process) of Riboflavin (HY-B0456) .

HY-172742

Dioctanoyl PI(3,4)P2 sodium	Biochemical Assay Reagents	Others
Dioctanoyl PI(3,4)P2 (sodium) is a synthetic analog of natural Ptdlns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. Dioctanoyl PI(3,4)P2 (sodium) contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural Ptdlns .

HY-35034

L-Isoleucic acid (2S,3S)-2-Hydroxy-3-methylpentanoic acid	Amino Acid Derivatives Drug Intermediate	Others
L-Isoleucic acid ((2S,3S)-2-Hydroxy-3-methylpentanoic acid) ((S)-isoleucic acid) is a non-proteinogenic amino acid derivative. L-Isoleucic acid can be used as a key synthetic building block to construct JBIR-39 .

HY-N12970

14S(15R)-EET	Others	Others
14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .

HY-114461A

(16R,17S)-FD-895	Drug Derivative	Cancer
(16R,17S)-FD-895, a similar compound to FD-895 (HY-114461), is a potent in vivo splice regulatory agent. (16R,17S)-FD-895 retains the similar anti-proliferative activity as FD-895. (16R,17S)-FD-895 can be used for research on colon cancer .

HY-N18270

9α-epi-Tuberospironine A	Others	Others
9α-epi-Tuberospironine A is a croomine-type stemona alkaloid found in the roots of Stemona tuberosa .

HY-N18043

Rehmaglutin C	Drug Derivative	Others
Rehmaglutin C is an iridoid lactone.Rehmaglutin C can be found in the dried root of Rehmannia glutinosa LiBosCH .

HY-119781

Kaitocephalin PF1191	iGluR	Neurological Disease
Kaitocephalin (PF1191) is an ionotropic glutamate receptor (NMDAR) antagonist with K_i values of 7.8, 590, and 14000 nM for NMDAR, AMPAR, and KAR, respectively. Kaitocephalin protects neurons by inhibiting excitotoxicity, exhibiting neuroprotective effects. Kaitocephalin can be used in research on neurological diseases such as Alzheimer's disease .

Cat. No.	Product Name	Type

HY-W010394

Methyl 3-oxopentanoate	Biochemical Assay Reagents
Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.

Methyl 3-oxopentanoate

Biochemical Assay Reagents

Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.

HY-W039854

1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose, 96% 1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranose, 96%	Biochemical Assay Reagents
1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose, 96% (1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranose, 96%) can be used in glycobiology research to study glycosylation mechanisms, glycosidic bond formation, and stereochemistry.

Cat. No.	Product Name	Target	Research Area

HY-126584

H-Val-Val-OH Val-Val	Drug Intermediate Oligopeptide Cotransporter	Others
H-Val-Val-OH (Val-Val) is a stereochemistry-dependent substrate and inhibitor of apical oligopeptide transporters. H-Val-Val-OH undergoes apical intracellular accumulation in human intestinal cells via carrier-mediated transport, and inhibits the uptake of Cephalexin (HY-B0200) through interaction with transporters. Substitution of L-valine with D-valine in H-Val-Val-OH abolishes its binding ability to apical oligopeptide transporters .

4-Methylumbelliferyl-β-D-xylopyranoside 4-Methylumbelliferyl-β-D-xyloside	Structural Classification Animals Coumarins Phenylpropanoids Source Classification	Biochemical Assay Reagents
4-Methylumbelliferyl-β-D-xylopyranoside (4-Methylumbelliferyl-β-D-xyloside) is an enzymatically hydrolyzable β-D-xylopyranoside substrate. The enzymatic hydrolysis of 4-Methylumbelliferyl-β-D-xylopyranoside is mediated by the stereochemistry-retaining β-D-xylosidase GSXynB2 via a two-step catalytic process (xylosylation followed by dexylosidation). 4-Methylumbelliferyl-β-D-xylopyranoside serves as a substrate for the β-xylosidase of Trichoderma reesei QM 9414, and its enzymatic hydrolysis process is limited by the dexylosidation step.

N-(3-Oxooctanoyl)-DL-homoserine lactone (Rac)-3-oxo-C8-HSL	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite
N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .

(3RS,7R,11R)-Dihydrophytol	Structural Classification Natural Products Microorganisms Source Classification	Drug Intermediate
(3RS, 7R, 11R)-Dihydrophytol is the hydrogenation intermediate in the synthesis of Phytanic acid (HY-113067) from Phytol (HY-N3075) .

11S(12R)-EET	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Others
11S(12R)-EET is a dominant enantiomer of epoxytrienoic acid (EET) that is metabolized at a higher rate in rat organs. It shows enantiomeric-dependent reaction selectivity in hydration, especially in the case of 11,12-EET, where water addition is non-regioselective, while in 8,9-EET, water addition occurs mainly at the C9 position. In addition, 11S(12R)-EET generates diol products with specific stereochemistry through enzymatic hydration reactions, which are affected by the selective recognition of epoxidases, reaction conversion rates, and substrate binding parameters .

Radicinol	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Bacterial
Radicinol is a metabolite of cochliobolus lunata, and absolute stereochemistry of radicinin .

3'R-HBHL	Structural Classification Natural Products Microorganisms Source Classification	Biochemical Assay Reagents
3'R-HBHL is a reference compound used for determining the stereochemistry of small bacteriocins .

14S(15R)-EET	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Others
14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .

9α-epi-Tuberospironine A	Structural Classification Alkaloids Pyrrole Alkaloids Stemonaceae Plants Stemona tuberosa Lour. Source Classification	Others
9α-epi-Tuberospironine A is a croomine-type stemona alkaloid found in the roots of Stemona tuberosa .

Rehmaglutin C	Structural Classification Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & C. A. Mey. Terpenoids Sesquiterpenes Orobanchaceae Plants Steroids Source Classification	Drug Derivative
Rehmaglutin C is an iridoid lactone.Rehmaglutin C can be found in the dried root of Rehmannia glutinosa LiBosCH .

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Stereochemistry

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