PLK4-IN-3
PLK4-IN-3 is a less active absolute stereochemistry of PLK4-IN-1. PLK4-IN-1 is a spiro cyclopropyl indolinone compound and PLK4 inhibitor with inhibitory activity against Aurora A and Aurora B kinases .PLK4-IN-1 can be used for the research of cancer .
For research use only. We do not sell to patients.
- CAS No.: 1247001-86-0
- Formula: C18H14IN3O2
- Molecular Weight:431.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PLK4 ≤ 0.1 μM (IC50) |
PLK4-IN-3 is a less active absolute stereochemistry of PLK4-IN-1. PLK4-IN-1 (compound A6) potently inhibits purified PLK4 kinase with an IC50 ≤ 0.1 μM. It inhibits purified Aurora A kinase, with an inhibition rate of less than 50% at an administration concentration of 1 μM. It also inhibits purified Aurora B kinase, with an IC50 greater than 0.1 μM and ≤ 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1247001-86-0
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Molecular Weight 431.23
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Formula C18H14IN3O2
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SMILES
O=C([C@@]12[C@H](C3=CC4=C(C=C3)C(I)=NN4)C1)NC5=C2C=C(OC)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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