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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
TRPML1 channel
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "TRPML1 channel" in MCE Product Catalog:
9
9 Publications Verification
Synonyms: ML-SI3 (cis/trans mix)
Target:
Research Areas:
ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively .
4
4 Cited Publications
Target:
Research Areas:
ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth .
1
1 Cited Publications
Cat. No.: HY-P5381
CAS No.: 329902-61-6
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Cat. No.: HY-W008581
CAS No.: 1035-77-4
Synonyms: 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
Research Areas:
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
Cat. No.: HY-P702374
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCOLN1; Transient Receptor Potential Mucolipin 1; Mucolipin TRP Cation channel 1; Mucolipin 1; TRPML1; Mucolipidin; ML4; Mucolipin-1; TRPM-L1; MG-2; MSTP080; ML1; MST080; Mucolipidosis Type IV Protein; MLIV; Mucolipidosis Type IV; Transient Receptor Poten
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-P701383
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCOLN1; Transient Receptor Potential Mucolipin 1; Mucolipin TRP Cation channel 1; Mucolipin 1; TRPML1; Mucolipidin; ML4; Mucolipin-1; TRPM-L1; MG-2; MSTP080; ML1; MST080; Mucolipidosis Type IV Protein; MLIV; Mucolipidosis Type IV; Transient Receptor Poten
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
