Search Result

Results for "

YAP/TEAD1 interaction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	YAP (7) Ligands for Target Protein for PROTAC (1) PROTACs (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Targets Recommended: YAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134955

VT103 5 Publications Verification	YAP	Cancer
VT103, an analog of VT101, is an orally active and selective *TEAD1* protein palmitoylation inhibitor. VT103 inhibits *YAP/TAZ-TEAD* promoted gene transcription, blocks *TEAD* auto-palmitoylation, and disrupts interaction between *YAP/TAZ* and *TEAD*. VT103 can be used for the research of cancer .

HY-174275

TEAD1/3/4-IN-1	YAP	Inflammation/Immunology Cancer
TEAD1/3/4-IN-1 is an orally active inhibitor of *TEAD1/3/4. TEAD1/3/4-IN-1 inhibits the YAP/TAZ-TEAD* interaction, with its EC₅₀ being 2 nM. TEAD1/3/4-IN-1 has anti-proliferative activity against NCI-H226 cells. TEAD1/3/4-IN-1 can be used in the research of lung squamous cell carcinoma .

HY-P2244A

YAP-TEAD-IN-1 TFA 2 Publications Verification	YAP	Cancer
YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of **YAP-TEAD interaction (IC₅₀*=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1* (K_d=15 nM) than YAP (50-171) (K_d= 40 nM) .

HY-P2244

YAP-TEAD-IN-1 2 Publications Verification	YAP	Cancer
YAP-TEAD-IN-1 is a potent and competitive inhibitor of?YAP–TEAD *interaction* (IC₅₀=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (K_d=15 nM) than YAP (50-171) (K_d=40 nM) .

HY-182673

VT102	YAP	Cancer
VT102 is a *TEAD1* inhibitor with a human IC₅₀ of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of *TEAD* target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer .

HY-186022

YAP/TAZ-TEAD-IN-3	Ligands for Target Protein for PROTAC YAP	Cancer
YAP/TAZ-TEAD-IN-3 is a *YAP/TAZ-TEAD* interaction inhibitor with an IC₅₀ of 1.8 nM. YAP/TAZ-TEAD-IN-3 can be used as a *TEAD1* ligand to construct PROTACs, such as PROTAC TEAD degrader-2 (HY-186021) .

HY-186021

PROTAC TEAD degrader-2	PROTACs YAP	Cancer
PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC₅₀ of 0.6 nM. PROTAC TEAD degrader-2 inhibits the *YAP/TAZ-TEAD* interaction, with a IC₅₀ of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma .

Cat. No.	Product Name	Target	Research Area

HY-P2244A

YAP-TEAD-IN-1 TFA 2 Publications Verification	YAP	Cancer
YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of **YAP-TEAD interaction (IC₅₀*=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1* (K_d=15 nM) than YAP (50-171) (K_d= 40 nM) .

HY-P2244

YAP-TEAD-IN-1 2 Publications Verification	YAP	Cancer
YAP-TEAD-IN-1 is a potent and competitive inhibitor of?YAP–TEAD *interaction* (IC₅₀=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (K_d=15 nM) than YAP (50-171) (K_d=40 nM) .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.