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Results for "

adenine base

" in MedChemExpress (MCE) Product Catalog:

12

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2

Peptides

3

Natural
Products

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12404
    Diminazene aceturate
    10+ Cited Publications

    Diminazene diaceturate

    		 Parasite Angiotensin-converting Enzyme (ACE) Infection Inflammation/Immunology
    Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .
    Diminazene aceturate
  • HY-W011548
    2-Aminoadenosine

    		Nucleoside Antimetabolite/Analog Others
    2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes .
    2-Aminoadenosine
  • HY-113303
    FAPy-adenine
    2 Publications Verification

    		 Endogenous Metabolite Neurological Disease Cancer
    FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases .
    FAPy-adenine
  • HY-112817
    8-Oxo-dGTP

    8-Oxo-Deoxyguanosine triphosphate

    		 Apoptosis Cardiovascular Disease Neurological Disease Cancer
    8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .
    8-Oxo-dGTP
  • HY-164770A
    Adenosyl-(3′→5′)-uridine sodium

    ApU sodium

    		 DNA/RNA Synthesis Others
    Adenosyl-(3′→5′)-uridine (ApU) sodium is a nucleotide, which is composed of an adenine base and a uracil sugar molecule through a 3'-5' phosphodiester bond. Adenosyl-(3′→5′)-uridine (ApU) sodium participates in the biological processes, such as gene expression regulation, signal transduction, and protein synthesis .
    Adenosyl-(3′→5′)-uridine sodium
  • HY-164770
    Adenosyl-(3′→5′)-uridine

    ApU

    		 DNA/RNA Synthesis Others
    Adenosyl-(3′→5′)-uridine (ApU) is a nucleotide, which is composed of an adenine base and a uracil sugar molecule through a 3'-5' phosphodiester bond. Adenosyl-(3′→5′)-uridine (ApU) participates in the biological processes, such as gene expression regulation, signal transduction, and protein synthesis .
    Adenosyl-(3′→5′)-uridine
  • HY-113303R
    FAPy-adenine (Standard)

    		Endogenous Metabolite Reference Standards Neurological Disease Cancer
    FAPy-adenine (Standard) is the analytical standard of FAPy-adenine. This product is intended for research and analytical applications. FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases .
    FAPy-adenine (Standard)
  • HY-E70582
    E.coli tRNA adenosine deaminase

    		Adenosine Deaminase Others
    E.coli tRNA adenosine deaminase is derived from E.coli and is an adenine deaminase that can deaminate adenine in single-stranded RNA (ssRNA, mainly the loop region within tRNA) or double-stranded RNA (dsRNA), but has no deamination activity on DNA. E.coli tRNA adenosine deaminase is a protein-modified mutant of adenine deaminase, which can efficiently deaminate adenine in ssDNA and can be applied to adenine base editors (ABE) and RNA m6A methylation sequencing .
    E.coli tRNA adenosine deaminase
  • HY-12404R
    Diminazene aceturate (Standard)

    Diminazene diaceturate (Standard)

    		 Reference Standards Parasite Angiotensin-converting Enzyme (ACE) Infection Inflammation/Immunology
    Diminazene (aceturate) (Standard) is the analytical standard of Diminazene (aceturate). This product is intended for research and analytical applications. Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .
    Diminazene aceturate (Standard)
  • HY-W540123
    Fmoc-PNA-A(Bhoc)-OH

    		Biochemical Assay Reagents Cancer
    Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration .
    Fmoc-PNA-A(Bhoc)-OH
  • HY-W784623
    Boc-PNA-A(Z)-OH

    		Drug Intermediate Others
    Boc-PNA-A(Z)-OH is a Boc-protected peptide nucleic acid monomer with a benzyloxycarbonyl protecting group on the adenine base .
    Boc-PNA-A(Z)-OH
  • HY-112817A
    8-Oxo-dGTP trisodium solution (100 mM)

    8-Oxo-Deoxyguanosine triphosphate trisodium

    		 Apoptosis Others
    8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) trisodium solution (100mM) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP trisodium solution (100mM) acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP trisodium solution (100mM) causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP trisodium solution (100mM) in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP trisodium solution (100mM) is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .
    8-Oxo-dGTP trisodium solution (100 mM)

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