1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. FAPy-adenine

FAPy-adenine 

Cat. No.: HY-113303
Handling Instructions

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases.

For research use only. We do not sell to patients.

FAPy-adenine Chemical Structure

FAPy-adenine Chemical Structure

CAS No. : 5122-36-1

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Description

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1].

In Vivo

The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1].

Molecular Weight

153.14

Formula

C₅H₇N₅O

CAS No.

5122-36-1

SMILES

O=CNC1=C(N)N=CN=C1N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FAPy-adenineEndogenous MetaboliteAlzheimer'sdiseaseDNAdamageoxygenbaseoxidativeInhibitorinhibitorinhibit

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