2096-10-8
Chemical Structure
2-Aminoadenosine
- CAS No.: 2096-10-8
- Formula:C10H14N6O4
- Molecular Weight:282.26
IUPAC Name: (2R,3R,4S,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: ZDTFMPXQUSBYRL-UUOKFMHZSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)N=C3N)=C3N=C2)O1
Biological Activity: 2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes[1][2].
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2-Aminoadenosine | 98.0% | 2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes. | ||||||||||||||||||||
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- [1]. Lamm GM, et al. Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts. Nucleic Acids Res. 1991;19(12):3193-3198. [Content Brief]
- [2]. Grzeskowiak K, et al. Template-directed synthesis with 2-aminoadenosine. J Mol Evol. 1984;21(1):81-83. [Content Brief]
Keywords
