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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
cGMP analog
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "cGMP analog" in MCE Product Catalog:
Cat. No.: HY-108548
CAS No.: 185246-32-6
Synonyms: Rp-8-Bromo-PET-cGMPS
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Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.
Cat. No.: HY-137665
CAS No.: 78080-27-0
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PET-cGMP is a cyclic guanosine monophosphate analog and an effective selective agonist of PKG I, the EC50 of PET-cGMP for PKG Iβ is 3.8 nM, while for PKG II, it's 193 nM .
Cat. No.: HY-131737
CAS No.: 78033-42-8
1-NH2-cGMP is an analog of cGMP .
Cat. No.: HY-P3774
CAS No.: 108703-67-9
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Cat. No.: HY-137639
CAS No.: 153660-03-8
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Sp-8-Br-cGMPS is an analog of cGMP. Sp-8-Br-cGMPS is an agonist for cGMP-gated cation channels (CNG channels), with an EC50 of 106.5 μM. Sp-8-Br-cGMPS induces the currents, without the ability to stabilize the channel open state as a full agonist .
Cat. No.: HY-134311
CAS No.: 115993-88-9
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8-NBD-cGMP is a fluorescent analog of cyclic guanosine monophosphate and a potent, membrane-permeable, fluorescent activator of cGMP-dependent protein kinase isozymes I α and I β. 8-NBD-cGMP is barely fluorescent in aqueous solution but fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites
Cat. No.: HY-131824
CAS No.: 142754-31-2
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5,6-DM-cBIMP, a cyclic nucleotide analog, is an agonist of PDE2 that can significantly enhance the cAMP and cGMP hydrolytic activities of PDE2 [2.
Cat. No.: HY-131823
CAS No.: 129693-10-3
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5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolytic activities of PDE2 .
Cat. No.: HY-187175
CAS No.: 2172940-88-2
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Rp-8-Br-pME-PET-cGMPS is a cGMP (HY-113469) analog. Rp-8-Br-pME-PET-cGMPS is used for research on retinal dystrophy, retinitis pigmentosa, Stargardt disease, and macular degeneration .
Cat. No.: HY-180473
CAS No.: 57521-53-6
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6-Thio-cGMP is an analog of cyclic guanosine monophosphate (cGMP) .
Cat. No.: HY-P11861
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
