129693-10-3
129693-10-3
Chemical Structure
5,6-DCl-cBIMP
- CAS No.: 129693-10-3
- Formula:C12H11Cl2N2O6P
- Molecular Weight:381.11
IUPAC Name: (4aR,6R,7R,7aS)-6-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide
InChIKey: KJGQVDHRLMVVJK-DDHJBXDOSA-N
SMILES: O[C@@H]1[C@H](O2)[C@@H](COP2(O)=O)O[C@H]1N(C=N3)C4=C3C=C(Cl)C(Cl)=C4
Biological Activity: 5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolytic activities of PDE2[1][2].
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5,6-DCl-cBIMP | 5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolytic activities of PDE2. | |||||||||||||||||||||
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References
- [1]. McMartin L, et al. Functional analysis of desensitization of the β‐adrenoceptor signalling pathway in rat cardiac tissues following chronic isoprenaline infusion[J]. British journal of pharmacology, 1999, 127(4): 1012-1020. [Content Brief]
- [2]. Jäger R, et al. Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5[J]. British journal of pharmacology, 2010, 161(7): 1645-1660. [Content Brief]
