Search Result
Results for "
cap-dependent
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-109025A
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Baloxavir
Maximum Cited Publications
46 Publications Verification
Baloxavir acid; S-033447
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Influenza Virus
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Infection
Cancer
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Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-109025
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S-033188; RG 6152
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Influenza Virus
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Infection
Cancer
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Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
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- HY-14427
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- HY-132894
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Influenza Virus
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Infection
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Pixavir marboxilo is an orally active cap-dependent endonuclease inhibitor with high potency. Pixavir marboxilo can be used for the research of influenza .
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- HY-143744
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GP681; cap-dependent endonuclease-IN-3
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Endonuclease
Influenza Virus
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Infection
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Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases .
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- HY-21586B
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m7GTP sodium
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Nucleoside Antimetabolite/Analog
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Others
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7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate sodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
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- HY-109025R
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S-033188 (Standard); RG 6152 (Standard)
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Reference Standards
Influenza Virus
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Infection
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Baloxavir marboxil (Standard) is the analytical standard of Baloxavir marboxil. This product is intended for research and analytical applications. Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
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- HY-145969
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3'-O-Me-m7G(5')ppp(5')G
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DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
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Cancer
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β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA has been applied in researching experimental mRNA-based anticancer vaccines .
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- HY-177555
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Influenza Virus
Endonuclease
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Infection
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AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections .
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- HY-145969A
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3’-O-Me-m7G(5')ppp(5')G triammonium
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DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
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Cancer
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β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) triammonium is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA triammonium binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA triammonium prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA triammonium has been applied in researching experimental mRNA-based anticancer vaccines .
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- HY-164927
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- HY-139098
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m7Gp3G
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DNA/RNA Synthesis
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Others
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7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
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- HY-143769
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cap-dependent endonuclease-IN-15
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Influenza Virus
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Infection
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Sebaloxavir marboxil (Cap-dependent endonuclease-IN-15) (Compound c-1) is a potent inhibitor of cap-dependent endonuclease (CEN). Sebaloxavir marboxil inhibits the replication of influenza virus. Sebaloxavir marboxil has the potential for the research of viral infections caused by influenza viruses .
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- HY-143776
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- HY-143762
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1 .
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- HY-143770
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .
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- HY-143749
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-6 (compound 13) is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-6 shows inhibition against influenza virus (EC50=38.21 nM) .
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- HY-143768
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-14 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-14 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-14 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113620948A, compound 1-c) .
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- HY-144065
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DNA/RNA Synthesis
Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) .
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- HY-143781
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains .
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- HY-144068
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-25 is a macrocyclic pyridotriazine derivative. Cap-dependent endonuclease-IN-25 has the potential for the research of viral infections caused by viruses belonging to the Orthomyxoviridae family (extracted from patent WO2020075080A1, compound 4) .
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- HY-143775
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-20 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-20 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 of 4.82 μM (CN112940009A; DSC801) .
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- HY-143771
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-17 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-17 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 of 1.29 μM (CN112898346A; DSC701) .
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- HY-143766
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-13 has the potential for the research of influenza virus infection (only influenza A) (extracted from patent WO2021180147A1, compound I-1) .
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- HY-143752
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-8 inhibits replication of orthomyxoviruses (including influenza A, influenza B and influenza C) (extracted from patent CN111410661A, compound I-196) .
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- HY-143747
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties (extracted from patent WO2020078401A1, compound 13-1) .
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- HY-144066
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A) .
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- HY-144067
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-23 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-23 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-23 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8A or 8B) .
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- HY-143750
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-7 Inhibits the synthesis of viral mRNA and eventually inhibits virus proliferation. Cap-dependent endonuclease-IN-7 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2020177715A1, compound 5)
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- HY-143755
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DNA/RNA Synthesis
Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-9 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-9 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-9 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN112521386A, compound VI-1) .
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- HY-143743
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DNA/RNA Synthesis
Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-2 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-2 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent WO2019052565A1, compound 28) .
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- HY-143757
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1) .
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- HY-162242
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC50 = 12.26 nM) .
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- HY-163621
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-28 (Compound 11) is a potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-28 inhibits CEN of TOSV, ANDV, and LACV viruses with IC50 values of 2.4, 0.5, and 4 μM, respectively .
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- HY-148664
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Eukaryotic Initiation Factor (eIF)
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Cancer
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eIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical
activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .
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- HY-109025AS
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Baloxavir acid-d5; S-033447-d5
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Isotope-Labeled Compounds
Influenza Virus
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Infection
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Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-109025AR
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Baloxavir acid (Standard); S-033447 (Standard)
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Reference Standards
Influenza Virus
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Infection
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Baloxavir (Standard) is the analytical standard of Baloxavir. This product is intended for research and analytical applications. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-W751835
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Baloxavir acid-d4; S-033447-d4
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Isotope-Labeled Compounds
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Others
Cancer
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Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-155676
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- HY-153570
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Influenza Virus
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Infection
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Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases .
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- HY-21586
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m7GTP disodium
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Nucleoside Antimetabolite/Analog
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Metabolic Disease
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7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate disodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
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- HY-21586A
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7-Methyl-guanosine-5'-triphosphate
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Nucleoside Antimetabolite/Analog
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Metabolic Disease
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7-Methyl-guanosine-5'-triphosphate (m7GTP) is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate phosphorothioate analog is a potent cap-dependent translation inhibitor .
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- HY-109025AS2
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Baloxavir acid-d1; S-033447-d1
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Isotope-Labeled Compounds
Influenza Virus
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Infection
Cancer
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Baloxavir-d1 is the deuterium labeled Baloxavir (HY-109025A). Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-178672A
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Anti-Reverse cap analog triammonium solution (100 mM); m2 7,3′O GpppG triammonium solution (100 mM)
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DNA/RNA Synthesis
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Cancer
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ARCA (Anti-Reverse cap analog) triammonium solution (100 mM) is a 5′-cap analogue. ARCA triammonium solution (100 mM) caps mRNA. ARCA triammonium solution (100 mM) can be used in protein expression studies .
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| Cat. No. |
Product Name |
Type |
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- HY-21586B
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m7GTP sodium
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Biochemical Assay Reagents
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7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate sodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
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- HY-139098
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m7Gp3G
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Biochemical Assay Reagents
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7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-109025AS
-
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Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-W751835
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Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-109025AS2
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Baloxavir-d1 is the deuterium labeled Baloxavir (HY-109025A). Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
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| Cat. No. |
Product Name |
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Classification |
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- HY-21586B
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m7GTP sodium
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Nucleotide Analogs
Guanine Nucleotide
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7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate sodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
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- HY-145969
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3'-O-Me-m7G(5')ppp(5')G
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Cap Analogs
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β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA has been applied in researching experimental mRNA-based anticancer vaccines .
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- HY-145969A
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3’-O-Me-m7G(5')ppp(5')G triammonium
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Cap Analogs
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β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) triammonium is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA triammonium binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA triammonium prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA triammonium has been applied in researching experimental mRNA-based anticancer vaccines .
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- HY-139098
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m7Gp3G
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Cap Analogs
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7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
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- HY-21586
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m7GTP disodium
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Nucleotide Analogs
Guanine Nucleotide
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7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate disodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
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- HY-21586A
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7-Methyl-guanosine-5'-triphosphate
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Nucleoside Analogs
Nucleotide Analogs
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7-Methyl-guanosine-5'-triphosphate (m7GTP) is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate phosphorothioate analog is a potent cap-dependent translation inhibitor .
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