46 Results for "

citrulline

" in MedChemExpress (MCE) Product Catalog:
Products (46)

46 Results for "citrulline" in MCE Product Catalog:

97
97 Publications Verification
Cat. No.: HY-15575
CAS No.: 646502-53-6
Purity:  99.94%
Synonyms: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
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6
6 Cited Publications
Cat. No.: HY-N0391
CAS No.: 372-75-8
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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6
6 Cited Publications
Cat. No.: HY-20336
CAS No.: 159857-81-5
Synonyms: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
Target:  

ADC Linkers

Research Areas:  

Others Inflammation/Immunology Cancer

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs .
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6
6 Cited Publications
Cat. No.: HY-N0391A
CAS No.: 70796-17-7
L-Citrulline (DL-malate) is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate also plays an important role in some industrial fields, for example, it is used in the field of agriculture to enhance plant immunity.
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5
5 Cited Publications
Cat. No.: HY-W142119
CAS No.: 2792-66-7
Target:  

Ser/Thr Protease

Research Areas:  

Neurological Disease

α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine .
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Cat. No.: HY-171265
Synonyms: MRG003
Becotatug vedotin (MRG003) is an Antibody-Drug Conjugate (ADC) that consists of an anti-EGFR humanized IgG1 monoclonal antibody Becotatug (HY-P990049) and MMAE (HY-15162). These two parts are connected through a valine-citrulline (valine-citrulline) linker, where the linker and MMAE constitute the ADC's Drug-Linker conjugate VcMMAE (HY-15575) .
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Cat. No.: HY-N0391S5
CAS No.: 2483831-24-7
L-Citrulline-d7 is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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Cat. No.: HY-P99829
CAS No.: 1869937-48-3
Synonyms: PF-06647020; ABBV-647; h6M24-vc0101
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
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Cat. No.: HY-W016733
CAS No.: 13594-51-9
Synonyms: H-D-Cit-OH
Target:  

Endogenous Metabolite

Research Areas:  

Cardiovascular Disease

D-Citrulline (H-D-Cit-OH) is a stereoisomer of L-citrulline (HY-N0391). D-Citrulline significantly attenuates polymorphonuclear leukocyte (PMN)-induced cardiac contractile dysfunction in the isolated perfused rat heart subjected to ischemia/reperfusion via a non-NO-mediated mechanism .
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Cat. No.: HY-W018004
CAS No.: 1190-49-4
L-Homocitrulline is a carbamoylated derivative amino acid and a structural analog of L-citrulline. L-Homocitrulline serves not only as an intermediate in polypeptide synthesis but also converts into a variety of cyclic derivatives under enzymatic or acidic conditions. The level of L-Homocitrulline is significantly elevated in the serum of patients with non-alcoholic fatty liver disease (NAFLD), with high diagnostic accuracy. L-Homocitrulline also exists in patients with related diseases such as hypercitrullinemia. L-Homocitrulline is a key biomarker for monitoring abnormal liver metabolism and is widely used in NAFLD research .
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Cat. No.: HY-15575S
Purity:  97.56%
Synonyms: MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .
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Cat. No.: HY-N0391S4
CAS No.: 1217474-00-4
L-Citrulline-d4 is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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Cat. No.: HY-P5242
CAS No.: 960531-53-7
Synonyms: T10-C
Target:  

Peptides

Research Areas:  

Others

Tripeptide-10 citrulline (T10-C) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
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Cat. No.: HY-N0391R
CAS No.: 372-75-8
L-Citrulline (Standard) is the analytical standard of L-Citrulline. This product is intended for research and analytical applications. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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Cat. No.: HY-N0391S3
CAS No.: 94740-46-2
L-Citrulline- 13C is the 13C-labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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Cat. No.: HY-P990049
CAS No.: 2648260-93-7
Synonyms: JMT-101; MRG003 Antibody

Target:  

EGFR ADC Antibodies

Research Areas:  

Cancer

Becotatug (JMT-101) is a humanized IgG1 monoclonal antibody targeting epidermal growth factor receptor (EGFR), and serves as the antibody component of the antibody-drug conjugate Becotatug vedotin (HY-171265). Becotatug specifically binds to the extracellular domain of EGFR, induces receptor internalization and degradation, blocks the EGFR signaling pathway, and mediates antibody-dependent cellular cytotoxicity. When conjugated to monomethyl auristatin E (MMAE) (HY-15162) via a valine-citrulline cleavable linker, Becotatug enables targeted delivery of cytotoxic drugs to EGFR-positive tumor cells. Becotatug can be used for research related to non-small cell lung cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma. .
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Cat. No.: HY-W008064
CAS No.: 133174-15-9
Synonyms: Fmoc-L-citrulline
Research Areas:  

Cancer

Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
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Cat. No.: HY-170534
CAS No.: 2921734-44-1
Target:  

ADC Linkers

Research Areas:  

Cancer

Ac-EEVC-OH is a ADC Linker that can be used for the synthesis of ADC molecules .
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Cat. No.: HY-143678
CAS No.: 2468149-70-2
Research Areas:  

Others

Citrulline-specific probe-biotin is a biotinylated probe for detection of citrulline. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-biotin is a biological probe that can identify diseases showing abnormal increases in PAD activity .
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Cat. No.: HY-P2966
CAS No.: 75536-80-0
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Protein-arginine deiminase is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline .
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