1190-49-4
Chemical Structure
L-Homocitrulline
- CAS No.: 1190-49-4
- Formula:C7H15N3O3
- Molecular Weight:189.21
IUPAC Name: N6-carbamoyl-L-lysine
InChIKey: XIGSAGMEBXLVJJ-YFKPBYRVSA-N
SMILES: [H][C@](N)(CCCCNC(N)=O)C(O)=O
Biological Activity: L-Homocitrulline is a carbamoylated derivative amino acid and a structural analog of L-citrulline. L-Homocitrulline serves not only as an intermediate in polypeptide synthesis but also converts into a variety of cyclic derivatives under enzymatic or acidic conditions. The level of L-Homocitrulline is significantly elevated in the serum of patients with non-alcoholic fatty liver disease (NAFLD), with high diagnostic accuracy. L-Homocitrulline also exists in patients with related diseases such as hypercitrullinemia. L-Homocitrulline is a key biomarker for monitoring abnormal liver metabolism and is widely used in NAFLD research[1][2][3].
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L-Homocitrulline | 99.53% | L-Homocitrulline is a carbamoylated derivative amino acid and a structural analog of L-citrulline. L-Homocitrulline serves not only as an intermediate in polypeptide synthesis but also converts into a variety of cyclic derivatives under enzymatic or acidic conditions. The level of L-Homocitrulline is significantly elevated in the serum of patients with non-alcoholic fatty liver disease (NAFLD), with high diagnostic accuracy. L-Homocitrulline also exists in patients with related diseases such as hypercitrullinemia. L-Homocitrulline is a key biomarker for monitoring abnormal liver metabolism and is widely used in NAFLD research. | ||||||||||||||||||||
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L-Homocitrulline (Standard) | 99.96% | L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI). | ||||||||||||||||||||
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L-Homocitrulline-d3 | 98.8% | L-Homocitrulline-d3 is the deuterium labeled L-Homocitrulline. L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI). | ||||||||||||||||||||
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References
- [1]. Jia G G, et al. A novel preparation of L-citrulline and L-homocitrulline[J]. J. Chem. Soc. Pak, 2012, 34: 451-454.
- [2]. Yang Y, et al. Serum metabolomic profiling reveals an increase in homocitrulline in Chinese patients with nonalcoholic fatty liver disease: a retrospective study. PeerJ. 2021;9:e11346. Published 2021 May 3. [Content Brief]
- [3]. Wilson R W, et al. NEW METABOLITE OF L-HOMOCITRULLINE[C]//FEDERATION PROCEEDINGS. 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL, 1976, 35(7): 1478-1478.
