α-Methyl-DL-aspartic acid

Name: α-Methyl-DL-aspartic acid
Brand: MedChemExpress
SKU: HY-W142119
Rating: 4.5 (1 reviews)

Cat. No.: HY-W142119 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-Methyl-DL-aspartic acid Chemical Structure

CAS No. : 2792-66-7

Size	Price	Stock	Quantity
5 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine^[1].

In Vitro

α-methyl-dl-aspartic acid can significantly reduce the anti-hypertensive activity of Bj-BPP-10c in SHR^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

α-methyl-dl-aspartic acid (147 mg/kg, i.v.) can diminish the l-citrulline-induced retinal vasodilation in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats
Dosage:	147 mg/kg
Administration:	147 mg/kg, i.v.
Result:	Attenuated the increase of retinal arteriolar diameter induced by L-citrulline.

Molecular Weight

147.13

Formula

C₅H₉NO₄

CAS No.

2792-66-7

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (339.84 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7967 mL	33.9836 mL	67.9671 mL
5 mM	1.3593 mL	6.7967 mL	13.5934 mL
10 mM	0.6797 mL	3.3984 mL	6.7967 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (248 KB) HNMR (233 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Asami Mori, et al. l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015 Apr;127(4):419-23. [Content Brief]

[2]. Juliano R Guerreiro, et al. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. J Biol Chem. 2009 Jul 24;284(30):20022-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.7967 mL	33.9836 mL	67.9671 mL	169.9178 mL
	5 mM	1.3593 mL	6.7967 mL	13.5934 mL	33.9836 mL
	10 mM	0.6797 mL	3.3984 mL	6.7967 mL	16.9918 mL
	15 mM	0.4531 mL	2.2656 mL	4.5311 mL	11.3279 mL
	20 mM	0.3398 mL	1.6992 mL	3.3984 mL	8.4959 mL
	25 mM	0.2719 mL	1.3593 mL	2.7187 mL	6.7967 mL
	30 mM	0.2266 mL	1.1328 mL	2.2656 mL	5.6639 mL
	40 mM	0.1699 mL	0.8496 mL	1.6992 mL	4.2479 mL
	50 mM	0.1359 mL	0.6797 mL	1.3593 mL	3.3984 mL
	60 mM	0.1133 mL	0.5664 mL	1.1328 mL	2.8320 mL
	80 mM	0.0850 mL	0.4248 mL	0.8496 mL	2.1240 mL
	100 mM	0.0680 mL	0.3398 mL	0.6797 mL	1.6992 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Methyl-DL-aspartic acid2792-66-7Othersargininosuccinate synthase (ASS)rate-limiting enzymeneurosurgeryInhibitorinhibitorinhibit

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α-Methyl-DL-aspartic acid

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