α-Methyl-DL-aspartic acid
Based on 5 publication(s) in Google Scholar
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 2792-66-7
- Formula: C5H9NO4
- Molecular Weight:147.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-Methyl-DL-aspartic acid
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Customer Validation & Images
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Flow Cytometry
Biological Activity
α-methyl-dl-aspartic acid can significantly reduce the anti-hypertensive activity of Bj-BPP-10c in SHR[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats
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Dosage:147 mg/kg
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Administration:147 mg/kg, i.v.
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Result:Attenuated the increase of retinal arteriolar diameter induced by L-citrulline.
Chemical Information
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CAS No. 2792-66-7
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Appearance Solid
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Molecular Weight 147.13
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Formula C5H9NO4
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response. [Abstract]2024 Apr 2;15(1):2842. PMID: 38565558
α-Methyl-DL-aspartic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 2;15(1):2842. [Abstract]
Mice in the CT+α-MDLA group received intraperitoneal injections of 14 mg α-MDLA twice daily. On day 0, mice in the CDI, CDI + T.mu, and CT+α-MDLA groups were inoculated with Clostridium difficile spores. Cecum and colon were collected from designated mice on day 2 post-infection. Arginine levels in cecal contents were analyzed.
α-Methyl-DL-aspartic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 2;15(1):2842. [Abstract]
α-Methyl-DL-aspartic acid (14 mg α-MDLA). Representative HE-stained micrographs of macroscopic colonic and cecal tissue sections.
α-Methyl-DL-aspartic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 2;15(1):2842. [Abstract]
α-Methyl-DL-aspartic acid (14 mg α-MDLA). Representative flow cytometry plots and the percentage and number of neutrophils in the lamina propria of the colon.
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Sci Adv
Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia. [Abstract]2025 Aug 29;11(35):eadu6271. PMID: 40880474 -
iScience
2026 Jun 23;29(7):116159. PMID: 42389588 -
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Solvent & Solubility
H2O : 50 mg/mL (339.84 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Asami Mori, et al. l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015 Apr;127(4):419-23. [Content Brief]
[2]. Juliano R Guerreiro, et al. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. J Biol Chem. 2009 Jul 24;284(30):20022-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 6.7967 mL | 33.9836 mL | 67.9671 mL | 169.9178 mL |
| 5 mM | 1.3593 mL | 6.7967 mL | 13.5934 mL | 33.9836 mL | |
| 10 mM | 0.6797 mL | 3.3984 mL | 6.7967 mL | 16.9918 mL | |
| 15 mM | 0.4531 mL | 2.2656 mL | 4.5311 mL | 11.3279 mL | |
| 20 mM | 0.3398 mL | 1.6992 mL | 3.3984 mL | 8.4959 mL | |
| 25 mM | 0.2719 mL | 1.3593 mL | 2.7187 mL | 6.7967 mL | |
| 30 mM | 0.2266 mL | 1.1328 mL | 2.2656 mL | 5.6639 mL | |
| 40 mM | 0.1699 mL | 0.8496 mL | 1.6992 mL | 4.2479 mL | |
| 50 mM | 0.1359 mL | 0.6797 mL | 1.3593 mL | 3.3984 mL | |
| 60 mM | 0.1133 mL | 0.5664 mL | 1.1328 mL | 2.8320 mL | |
| 80 mM | 0.0850 mL | 0.4248 mL | 0.8496 mL | 2.1240 mL | |
| 100 mM | 0.0680 mL | 0.3398 mL | 0.6797 mL | 1.6992 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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