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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
complement-mediated diseases
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "complement-mediated diseases" in MCE Product Catalog:
13
13 Publications Verification
Synonyms: LNP023
Target:
Forschungsgebiete:
Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
13
13 Publications Verification
Synonyms: LNP023 hydrochloride
Target:
Forschungsgebiete:
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
1
1 Cited Publications
Art. -Nr.: HY-P3252A
Target:
Forschungsgebiete:
Art. -Nr.: HY-P99965
CAS. Nr.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107
Target:
Forschungsgebiete:
Art. -Nr.: HY-NP004
Synonyms: CVF
Art. -Nr.: HY-P99050
CAS. Nr.: 2049079-64-1
Synonyms: BIVV009; IPN-009; TNT009
Target:
Forschungsgebiete:
Art. -Nr.: HY-P990091
CAS. Nr.: 2756228-76-7
Synonyms: SAR 445088
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Forschungsgebiete:
Art. -Nr.: HY-145720
CAS. Nr.: 1639264-46-2
Synonyms: ALN-CC5
Forschungsgebiete:
Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
Art. -Nr.: HY-P99786
CAS. Nr.: 2096328-94-6
Synonyms: REGN3918
Target:
Forschungsgebiete:
Art. -Nr.: HY-145720A
Reinheit: 96.02%
Synonyms: ALN-CC5 sodium
Forschungsgebiete:
Cemdisiran sodium (ALN-CC5 sodium) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran sodium targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran sodium exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran sodium achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran sodium can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
Art. -Nr.: HY-P991513
Target:
Forschungsgebiete:
Art. -Nr.: HY-200854
CAS. Nr.: 2447007-60-3
Synonyms: LNP023 hydrochloride hydrate
Target:
Forschungsgebiete:
Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
Art. -Nr.: HY-178284
Target:
Forschungsgebiete:
Factor B-IN-7 (Compound (I)) is a selective Factor B inhibitor. Factor B-IN-7 inhibits Factor B-C3b interaction to suppress complement hyperactivation. Factor B-IN-7 is promising for research of paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy, and age-related macular degeneration (AMD) associated with complement-mediated diseases .
Art. -Nr.: HY-P990649
CAS. Nr.: 1169717-01-4
Synonyms: TRU-015
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Forschungsgebiete:
Art. -Nr.: HY-127105B
CAS. Nr.: 1644670-38-1
Synonyms: LNP023 TFA
Target:
Forschungsgebiete:
Iptacopan (LNP023) TFA is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan TFA exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan TFA can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
Art. -Nr.: HY-P3252AS
Forschungsgebiete:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
