717 Results for "

deuterated

" in MedChemExpress (MCE) Product Catalog:
Products (717)

717 Results for "deuterated" in MCE Product Catalog:

10
MMAE-d8
MMAE-d8
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10 Publications Verification
Cat. No.: HY-15162A
CAS No.: 2070009-72-0
Purity:  99.15%
Synonyms: Monomethyl auristatin E-d8; deuterated labeled MMAE
MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
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2
Phenylacetylglutamine-d5
Phenylacetylglutamine-d5
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2 Cited Publications
Cat. No.: HY-W050026S
CAS No.: 1331909-01-3
Synonyms: NSC 203800-d5; Phenylacetyl-L-glutamine-d5
Phenylacetylglutamine-d5 (NSC 203800-d5) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .
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1
Naringenin-d4
Naringenin-d4
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1 Cited Publications
Cat. No.: HY-N0100S
CAS No.: 1192260-78-8
Naringenin-d4 is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity .
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1
MMAF-d8 hydrochloride
MMAF-d8 hydrochloride
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1 Cited Publications
Cat. No.: HY-15579AS
Purity:  99.70%
MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
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1
Girard's Reagent P-d5
Girard's Reagent P-d5
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1 Cited Publications
Cat. No.: HY-W778336
CAS No.: 1505505-87-2
Girard's Reagent P-d5 is a deuterated labeled Girard's Reagent P-d5 .
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1
Maxacalcitol-d6
Maxacalcitol-d6
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1 Cited Publications
Cat. No.: HY-15329
CAS No.: 2070009-38-8
Purity:  99.63%
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
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1
Ivacaftor-d9
Ivacaftor-d9
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1 Cited Publications
Cat. No.: HY-13017S
CAS No.: 1413431-07-8
Purity:  99.83%
Synonyms: VX-770-d9
Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .
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1
DPPC-13C2
DPPC-13C2
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1 Cited Publications
Cat. No.: HY-109506S9
CAS No.: 65277-91-0
Purity:  ≥95.0%
Synonyms: 129Y83-13C2
DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
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1
Tacrolimus-13C,d2
Tacrolimus-13C,d2
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1 Cited Publications
Cat. No.: HY-13756S
CAS No.: 1356841-89-8
Purity:  98.36%
Synonyms: FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
Tacrolimus- 13C,d2 (FK506- 13C,d2) is the 13C, deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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1
L-Valine-d8
L-Valine-d8
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1 Cited Publications
Cat. No.: HY-I1124
CAS No.: 35045-72-8
Synonyms: L-VALINE-2,3,4,4,4,5,5,5-d8
L-Valine-d8 is a deuterated form of L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .
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1
Cyclosporin A-d4
Cyclosporin A-d4
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1 Cited Publications
Cat. No.: HY-B0579S
Synonyms: Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4
Cyclosporin A-d4 (Cyclosporine A-d4) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .
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1
Rapamycin-d3
Rapamycin-d3
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1 Cited Publications
Cat. No.: HY-10219S
CAS No.: 392711-19-2
Purity:  ≥93.0%
Synonyms: Sirolimus-d3; AY-22989-d3; NSC 226080-d3
Rapamycin-d3 (Sirolimus-d3; AY-22989-d3; NSC 226080-d3) is the deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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1
Sorafenib-d3
Sorafenib-d3
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1 Cited Publications
Cat. No.: HY-10201S
CAS No.: 1130115-44-4
Purity:  98.17%
Synonyms: Donafenib; Bay 43-9006-d3
Sorafenib-d3 (Donafenib) is the deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .
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1
Sorafenib-13C,d3
Sorafenib-13C,d3
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1 Cited Publications
Cat. No.: HY-10201S2
CAS No.: 1210608-86-8
Purity:  98.35%
Synonyms: Bay 43-9006-13C,d3
Sorafenib- 13C,d3 (Bay 43-9006- 13C,d3) is the 13C, deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .
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Exatecan-d5 mesylate
Exatecan-d5 mesylate
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Cat. No.: HY-13631AS
CAS No.: 2819276-88-3
Purity:  99.82%
Synonyms: DX8951f-d5; deuterated labeled Exatecan mesylate
Exatecan-d5 (DX8951f-d5) mesylate is deuterium labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research .
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Deuruxolitinib
Deuruxolitinib
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Cat. No.: HY-50856S
CAS No.: 1513883-39-0
Synonyms: CTP-543; Ruxolitinib d8; deuterated Ruxolitinib
Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), is an orally active JAK1 and JAK2 inhibitor. Deuruxolitinib demonstrates significant hair regrowth effects. Deuruxolitinib can be used for the research of alopecia areata .
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Cyclic AMP-13C5
Cyclic AMP-13C5
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Cat. No.: HY-B1511S
CAS No.: 2170095-23-3
Synonyms: Cyclic adenosine monophosphate-13C5; Adenosine cyclic 3', 5'-monophosphate-13C5; cAMP-13C5
Cyclic AMP- 13C5 is a deuterated cyclic AMP.
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Thiabendazole-d4
Thiabendazole-d4
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Cat. No.: HY-B0263S
CAS No.: 1190007-20-5
Synonyms: 2-(4-Thiazolyl)benzimidazole-d4
Thiabendazole-d4 is a deuterated form of Thiabendazole, which is an antiseptic, antifungal and antiparasitic agent .
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4-Acetamidobutanoic acid-d3
4-Acetamidobutanoic acid-d3
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Cat. No.: HY-101411S
Synonyms: N-acetyl GABA-d3
4-Acetamidobutanoic acid-d3 is the deuterated analog of 4-Acetamidobutanoic acid (HY-101411). 4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities .
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Isopentenyl pyrophosphate-13C2 ammonium
Isopentenyl pyrophosphate-13C2 ammonium
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Cat. No.: HY-W654241
Isopentenyl pyrophosphate- 13C2 is a deuterated labeled Isopentenyl pyrophosphate .
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