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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
dynein
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "dynein" in MCE Product Catalog:
6
6 Cited Publications
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .
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5 Cited Publications
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells .
Cat. No.: HY-175496
CAS No.: 2907705-12-6
Target:
Research Areas:
Acid Ceramidase-IN-3 is a acid ceramidase (aCDase) inhibitor. Acid Ceramidase-IN-3 inhibits the enzymatic activity of aCDase with a pIC 50 of 8.5 in enzymatic assays and 6.8 in A375 melanoma cellular assays. Acid Ceramidase-IN-3 promotes HSC inactivation, as measured by a dose-dependent
reduction in COL1A1 and ACTA2. Acid Ceramidase-IN-3 inhibits aCDase activity in HSCs, promotes HSC inactivation and suppresses YAP/TAZ nuclear localization. Acid Ceramidase-IN-3 increases Dynein/Kinesin (NDE1, NDEL1.
KIF3B, KIF15) while decreases several proteins involved with signaling pathway (SARM1, RGAP1,
PDGF-D,PDGFR-B). Acid Ceramidase-IN-3 can be used for the study of fibrotic diseases .
Cat. No.: HY-13224A
CAS No.: 758722-12-2
Target:
Research Areas:
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .
Cat. No.: HY-P1733
Synonyms: BMF-Y
Target:
Research Areas:
BMf-BH3 (BMF-Y) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 can be used in cancer-related research .
Cat. No.: HY-P810415
Synonyms: Axonemal dynein intermediate chain 1, Axonemal dynein intermediate chain 2, CILD 1, CILD1, Cytoplasmic dynein 1 intermediate chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein intermediate chain 1, Cytoplasmic dynein intermediate chain 2, DH IC 1, DH IC 2
Cat. No.: HY-P70048
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DYNLL1; dynein, Cytoplasmic, Light Polypeptide 1; Prev. DNCL1; 8 KDa dynein Light Chain; DLC1; DNCLC1; DLC8; Cytoplasmic dynein Light Polypeptide; PIN; dynein Light Chain; Hdlc1; HDLC1; LC8; LC8a; Protein Inhibitor Of Neuronal Nitric Oxide Synthase; Dynei
Cat. No.: HY-P11925
CAS No.: 934965-51-2
Target:
Research Areas:
Cat. No.: HY-P75947
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NUDC; Nuclear Distribution C Homolog (A. Nidulans); Nuclear Distribution C, dynein Complex Regulator; Nuclear Distribution Gene C Homolog; Nuclear Distribution Protein C Homolog; Nuclear Distribution C Homolog; NudC Nuclear Distribution Protein; NPD011; N
Cat. No.: HY-P1733A
Synonyms: BMF-Y TFA
Target:
Research Areas:
BMf-BH3 TFA (BMF-Y TFA) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 TFA binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 TFA can be used in cancer-related research .
Cat. No.: HY-P85488
Synonyms: 150 kDa dynein associated polypeptide; 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1; p150 Glued; Drosophila; homolog; dynactin 1; p150 glued homolog Drosophila; Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; p135; p150 Glued; Drosophila; homolog; p150 glued; p150 glued homolog; p150; GLUED; DROSOPHILA HOMOLOG OF; p150-glued; p150glued.
Cat. No.: HY-P71542
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DCTN1; Dynactin 1 (P150, Glued (Drosophila) Homolog); Dynactin Subunit 1; Dynactin 1 (P150, Glued Homolog, Drosophila); 150 KDa dynein-Associated Polypeptide; P150 Glued Homolog (Drosophila); DAP-150; Alternative Protein DCTN1; P150-Glued; DKFZp686E0752;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
