1. Stem Cell/Wnt
  2. Hedgehog
  3. Dynarrestin

Dynarrestin 

Cat. No.: HY-121802
Handling Instructions

Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.

For research use only. We do not sell to patients.

Dynarrestin Chemical Structure

Dynarrestin Chemical Structure

CAS No. : 2222768-84-3

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Description

Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells[1].

Molecular Weight

431.50

Formula

C₂₂H₂₃F₂N₃O₂S

CAS No.

2222768-84-3

SMILES

O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=CC=C(F)C=C3F)S1)OCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3175 mL 11.5875 mL 23.1750 mL
5 mM 0.4635 mL 2.3175 mL 4.6350 mL
10 mM 0.2317 mL 1.1587 mL 2.3175 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

DynarrestinHedgehogInhibitorinhibitorinhibit

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Dynarrestin
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