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ecdysteroid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Caspase (2) Drug Derivative (3) Drug Metabolite (1) Endogenous Metabolite (5) Environmental Pollutants (1) FXR (1) Insecticide (2) Insulin Receptor (1) Reference Standards (3)
By Research Areas:	Cardiovascular Disease (5) Endocrinology (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6979

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N1534

Ponasterone A 1 Publications Verification 25-Deoxyecdysterone	Others	Others
Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly .

HY-N2548

Turkesterone	Others	Cardiovascular Disease
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

HY-113890

Halofenozide RH-0345	Environmental Pollutants	Others
Halofenozide (RH-0345) is an *ecdysteroid* agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone .

HY-103273

Muristerone A	Endogenous Metabolite	Others
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a K_d of 1 nM .

HY-124097

HNMPA-(AM)3	Insulin Receptor	Metabolic Disease
HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC₅₀=14.2 μM) and insulin receptor activity (IC₅₀ is 14.2 μM and 200 μM in mosquitoes and mammals, respectively) .

HY-118541

RH-5849	Insecticide	Others
RH-5849 is an orally active agonist for non-steroidal ecdysteroid, which inhibits the larval growth of Plodia inferpuncteila in a dose-dependent manner. RH-5849 exhibits molting hormone activity .

HY-128030

Makisterone A	Others	Endocrinology
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

HY-N10746

Polyporoid C	Drug Derivative	Inflammation/Immunology
Polyporoid C is a ergostane-type ecdysteroid that exhibits potent anti-inflammatory activity in vivo .

HY-N10747

Polyporoid B	Drug Derivative	Inflammation/Immunology
Polyporoid B is a ergostane-type ecdysteroid that exhibits potent anti-inflammatory activity in vivo .

HY-N11081

Hexanorcucurbitacin D	FXR	Cardiovascular Disease
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD) .

HY-N2196

Ajugasterone C	Others	Inflammation/Immunology
Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats .

HY-N10382

20,26-Dihydroxyecdysone	Drug Metabolite	Others
20,26-Dihydroxyecdysone is a predominant ecdysteroid metabolite .

HY-N17267

2-Deoxy-20-hydroxyecdysone	Others	Infection
2-Deoxy-20-hydroxyecdysone is an ecdysteroid. 2-Deoxy-20-hydroxyecdyson can be isolated from zoanthid Zoanthus sp.. 2-Deoxy-20-hydroxyecdysone exhibits lower moulting hormone activity than 20-hydroxyecdysone in Musca bioassays .

HY-N2548R

Turkesterone (Standard)	Reference Standards Others	Cardiovascular Disease
Turkesterone (Standard) is the analytical standard of Turkesterone. This product is intended for research and analytical applications. Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

HY-N12156

Ajugasterone C 2-acetate	Others	Others
Ajugasterone C 2-acetate is an ecdysteroid that can be isolated from Cyanotis arachnoidea .

HY-113890R

Halofenozide (Standard) RH-0345 (Standard)	Others Reference Standards	Others
Halofenozide (Standard) is the analytical standard of Halofenozide. This product is intended for research and analytical applications. Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone .

HY-N6979R

Crustecdysone (Standard) 20-Hydroxyecdysone (Standard)	Reference Standards Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N12867

Amarasterone A	Others	Endocrinology
Amarasterone A (22) is an ecdysteroid that can be isolated from Rhaponticum carthamoides .

HY-N3792

20-Hydroxyecdysone 2,3:20,22-diacetonide	Others	Metabolic Disease
20-Hydroxyecdysone 2,3:20,22-diacetonide is a natural ecdysteroid .

HY-N18079

Dacryhainansterone	Drug Derivative	Others
Dacryhainansterone is an insect ecdysteroid receptor agonist with a pIC₅₀ of 7.64 M.Dacryhainansterone binds to the insect ecdysteroid receptor and activates it in a reporter gene assay .

HY-N15491

2-Deoxyecdysone	Endogenous Metabolite	Others
2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects .

HY-118989

Ajugalactone	Insecticide Endogenous Metabolite	Infection
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Cardiovascular Disease other families Animals Classification of Application Fields Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Disease Research Fields Steroids Source Classification	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

Ponasterone A 1 Publications Verification 25-Deoxyecdysterone	Podocarpus nakaii Hayata Classification of Application Fields Other Diseases Podocarpaceae Plants Disease Research Fields Steroids Source Classification	Others
Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly .

Turkesterone	Cardiovascular Disease other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Others
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

Muristerone A	Ipomoea nil (Linnaeus) Roth Classification of Application Fields Other Diseases Plants Convolvulaceae Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a K_d of 1 nM .

Makisterone A	Classification of Application Fields Chenopodium quinoa Willd. Plants Disease Research Fields Endocrinology Steroids Source Classification Chenopodiaceae	Others
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

Hexanorcucurbitacin D	Triterpenes Terpenoids Cucurbitaceae Trichosanthes cucumeroides (Ser.) Maxim. Plants Source Classification	FXR
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD) .

Ajugasterone C	Classification of Application Fields Ranunculaceae Plants Inflammation/Immunology Disease Research Fields Pulsatilla chinensis (Bunge) Regel Steroids Source Classification	Others
Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats .

2-Deoxy-20-hydroxyecdysone	Structural Classification Marine natural products Other marine organisms Steroids Source Classification	Others
2-Deoxy-20-hydroxyecdysone is an ecdysteroid. 2-Deoxy-20-hydroxyecdyson can be isolated from zoanthid Zoanthus sp.. 2-Deoxy-20-hydroxyecdysone exhibits lower moulting hormone activity than 20-hydroxyecdysone in Musca bioassays .

Turkesterone (Standard)	Structural Classification other families Plants Steroids Source Classification	Reference Standards Others
Turkesterone (Standard) is the analytical standard of Turkesterone. This product is intended for research and analytical applications. Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

Ajugasterone C 2-acetate	Structural Classification Commelinaceae Cyanotis arachnoidea C. B. Clarke Plants Steroids Source Classification	Others
Ajugasterone C 2-acetate is an ecdysteroid that can be isolated from Cyanotis arachnoidea .

Crustecdysone (Standard) 20-Hydroxyecdysone (Standard)	Structural Classification other families Animals Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Steroids Source Classification	Reference Standards Caspase Autophagy Endogenous Metabolite
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

Amarasterone A	Structural Classification Rhaponticum carthamoides (Willd.) Iljin Plants Compositae Steroids Source Classification	Others
Amarasterone A (22) is an ecdysteroid that can be isolated from Rhaponticum carthamoides .

20-Hydroxyecdysone 2,3:20,22-diacetonide	Triterpenes Terpenoids Rhaponticum carthamoides (Willd.) Iljin Plants Compositae Source Classification	Others
20-Hydroxyecdysone 2,3:20,22-diacetonide is a natural ecdysteroid .

Dacryhainansterone	Structural Classification Commelinaceae Cyanotis arachnoidea C. B. Clarke Plants Steroids Source Classification	Drug Derivative
Dacryhainansterone is an insect ecdysteroid receptor agonist with a pIC₅₀ of 7.64 M.Dacryhainansterone binds to the insect ecdysteroid receptor and activates it in a reporter gene assay .

2-Deoxyecdysone	Structural Classification Natural Products Animals Steroids Source Classification	Endogenous Metabolite
2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects .

Ajugalactone	Structural Classification Labiatae Plants Steroids Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Insecticide Endogenous Metabolite
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

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ecdysteroid

Inhibitors & Agonists

NaturalProducts

Natural
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