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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
endocrine disorders
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "endocrine disorders" in MCE Product Catalog:
2
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LysoPE (18:2/0:0) is a lysophosphatidylethanolamine implicated in phospholipid metabolism. LysoPE (18:2/0:0) shows significantly altered serum levels in mice exposed to a combination of DEHP (HY-B1945) and Aroclor 1254, which is associated with disturbed phospholipid metabolism. LysoPE (18:2/0:0) can be used for the research of endocrine-disrupting compound-induced metabolic disorders and lipid metabolism disturbance. LysoPE (18:2/0:0) is identified as a potential biomarker for the combined toxicity of DEHP and Aroclor 1254 .
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ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders.
Cat. No.: HY-A0278
CAS No.: 79983-71-4
Synonyms: (-)-Hexaconazol
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Hexaconazole is a demethylation enzyme inhibitor and a synthetic fungicide that targets many fungi, especially ascomycetes and basidiomycetes, and it can enhance the activity of SOD and peroxidase. Hexaconazole causes endocrine disorders in zebrafish larvae .
Cat. No.: HY-W036120
CAS No.: 131-55-5
Synonyms: 2,2′,4,4′-Tetrahydroxybenzophenone
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Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an organic ultraviolet absorber that is widely used in personal care products and industrial products such as plastics and coatings. Benzophenone-2 is an endocrine disruptor that can interfere with estrogen receptors (ERα receptor) and pregnane X receptor (PXR receptor) activity, leading to reproductive toxicity, immune disorders, and metabolic abnormalities. Benzophenone-2 can inhibit the activity of α-glucosidase (IC50 = 49.72 μM), and can be used for research on diabetes .
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The glutamic acid-alanine-glycine mixture is an orally active activator of testosterone 5α-reductase (5α-reductase). It promotes prostate function by enhancing the activity of 5α-reductase and increasing the levels of free amino acids. However, when combined with testosterone and estradiol (HY-B0141R), the glutamic acid-alanine-glycine mixture inhibits 5α-reductase activity and decreases the levels of free amino acids. The glutamic acid-alanine-glycine mixture can be used in research related to prostate function and endocrine disorders .
Cat. No.: HY-W040047S
Cat. No.: HY-P1723A
Synonyms: Neuropeptide Q TFA
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Cat. No.: HY-160548
CAS No.: 2170358-67-3
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Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
mTOR inhibitor-18 (Example 106) is a mTOR inhibitor. mTOR inhibitor-18 can be used for mTOR related research, such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders .
Cat. No.: HY-160168
CAS No.: 2662512-02-7
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BTK-IN-31 (Compound 2) is a selective, non-covalently reversible, and blood-brain barrier (BBB) permeable Btk inhibitor. BTK-IN-31 has research potential in immune disorders, cancer, cardiovascular disease, viral infections, inflammation, metabolic/endocrine dysfunction, and neurological disorders .
Cat. No.: HY-118091
CAS No.: 146117-78-4
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LY191704, as a benzoquinolinone, is a potent, nonsteroidal, noncompetitive and selective human type I 5α-reductase inhibitor. LY191704 is a racemic mixture of the compounds LY300502 and LY300503. LY191704 may be useful in the research of human endocrine disorders associated with overproduction of dihydrotestosterone (DHT) by 5α-reductase type 1 .
Cat. No.: HY-177278
CAS No.: 868057-23-2
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SST1 receptor antagonist-1 (Compound 23) is a selective Somatostatin receptor 1 (SST1) antagonist with pKds of 9.11 and 8.79 for rSST1 and hSST1, respectively. SST1 receptor antagonist-1 can be used for retinal and endocrine dysfunctions, cancer and neuropsychiatric disorders research .
Cat. No.: HY-N15342
CAS No.: 39380-16-0
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Cat. No.: HY-142932
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BTK-IN-6 is a potent inhibitor of Bruton's Tyrosine Kinase (BTK). BTK is a member of the Tec family of tyrosine kinases and plays an important role in the regulation of early B-cell development and mature B-cell activation and survival. BTK-IN-6 has the potential for the research of immune disorders, cancer, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders, and neurological disorders (extracted from patent WO2021136219A1, compound 8) .
Cat. No.: HY-13736
CAS No.: 87056-78-8
Synonyms: CV205-502
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Quinagolide (CV205-502) is a non-ergot dopamine D(2) receptor agonist that promotes dopamine activity. Quinagolide has shown effectiveness in modulating endocrine function, particularly in inhibiting disorders associated with dopamine deficiency. Quinagolide is used to suppress hyperprolactinemia and corresponding clinical symptoms, showing good efficacy. Quinagolide's biological activity enables its use as an important research compound in drug isolation and analysis .
Cat. No.: HY-W587442
CAS No.: 74192-35-1
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3-Chlorobisphenol A, a chlorinated derivatives of bisphenol A, is an endocrine-disrupting compound. It binds to estrogen receptors, causing disorders in hormone signaling pathways. Bisphenol A is an industrial chemical used in the production of polycarbonate plastics and epoxy resin.
Cat. No.: HY-184833
CAS No.: 2417137-50-7
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Tyk2-IN-25 is a TYK2 inhibitor that binds to the JH2 domain of TYK2. Tyk2-IN-25 inhibits p-STAT4 and p-STAT3 in human peripheral blood mononuclear cells. Tyk2-IN-25 is applicable to research related to multiple diseases such as immune and inflammatory diseases, and neurological diseases .
Cat. No.: HY-135446
CAS No.: 141595-53-1
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BQ-610 is a selective antagonist of the endothelin A receptor (ETA receptor). BQ-610 specifically blocks the ETA receptor, competitively inhibiting the binding of endothelin-1 (ET-1) (a vasoconstrictive peptide) to the receptor, thereby blocking the effects of ET-1 such as vascular smooth muscle contraction, cell mitosis, and inhibition of hormone secretion. BQ-610 significantly alleviates cerebral vasospasm in rabbits. BQ-610 blocks the bronchial epithelial and pulmonary vascular cell proliferation caused by cigarette smoke in rat models. BQ-610 can delay the natural luteal regression in the cow's uterus. BQ-610 can be used for research on vasospasm, abnormal cell proliferation, and reproductive endocrine disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
