131-55-5
Chemical Structure
Benzophenone-2
Synonym(s): 2,2′,4,4′-Tetrahydroxybenzophenone
- CAS No.: 131-55-5
- Formula:C13H10O5
- Molecular Weight:246.22
IUPAC Name: bis(2,4-dihydroxyphenyl)methanone
InChIKey: WXNRYSGJLQFHBR-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(O)C=C1O)C2=CC=C(O)C=C2O
Biological Activity: Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an organic ultraviolet absorber that is widely used in personal care products and industrial products such as plastics and coatings. Benzophenone-2 is an endocrine disruptor that can interfere with estrogen receptors (ERα receptor) and pregnane X receptor (PXR receptor) activity, leading to reproductive toxicity, immune disorders, and metabolic abnormalities. Benzophenone-2 can inhibit the activity of α-glucosidase (IC50 = 49.72 μM), and can be used for research on diabetes[1][2][3].
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Benzophenone-2 | 99.66% | Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an organic ultraviolet absorber that is widely used in personal care products and industrial products such as plastics and coatings. Benzophenone-2 is an endocrine disruptor that can interfere with estrogen receptors (ERα receptor) and pregnane X receptor (PXR receptor) activity, leading to reproductive toxicity, immune disorders, and metabolic abnormalities. Benzophenone-2 can inhibit the activity of α-glucosidase (IC50 = 49.72 μM), and can be used for research on diabetes. | ||||||||||||||||||||
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2,2′,4,4′-Tetrahydroxybenzophenone-d4 | 2,2′,4,4′-Tetrahydroxybenzophenone-d4 is deuterium labeled Bis(2,4-dihydroxyphenyl)methanone. | |||||||||||||||||||||
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References
- [1]. Hu X, et al. Evaluation of polyhydroxybenzophenones as α-glucosidase inhibitors. Arch Pharm (Weinheim). 2011 Feb;344(2):71-7. [Content Brief]
- [2]. Casiano-Muñiz IM, et al. UV filter benzophenone-2: Effects on zebrafish (Danio rerio) cytochrome P450. Aquat Toxicol. 2024 Aug;273:106973. [Content Brief]
- [3]. Broniowska Ż, et al. Benzophenone-2 exerts reproductive toxicity in male rats. Reprod Toxicol. 2023 Sep;120:108450. [Content Brief]
