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enteroviruses

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By Targets:	DNA/RNA Synthesis (2) DYRK (1) Enterovirus (12) Fluorescent Dye (1) HCV (1) NF-κB (1) PI4K (1) PROTACs (1) Reference Standards (1) RSV (1)
By Research Areas:	Infection (14) Inflammation/Immunology (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19952

Pleconaril 1 Publications Verification VP 63843; Win 63843	Enterovirus	Infection
Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. Pleconaril has potential for use in rhinoviruses and enteroviruses research .

HY-16561A

cis-Resveratrol 1 Publications Verification	Enterovirus NF-κB	Infection Inflammation/Immunology
cis-Resveratrol exhibits signifcant antiviral activity. cis-Resveratrol inhibits enteroviruses with IC₅₀s of 12.2 µM and 37.6 µM for coxsackievirus B3 (CVB3) and enterovirus 71 (EV71), respectively. cis-Resveratrol is the inhibitor for NF-κB signaling pathway .

HY-106312A

Enviroxime LY122772	Enterovirus	Infection
Enviroxime (LY122772) is an antiviral compound that inhibits the replication of rhinoviruses and *enteroviruses*. Enviroxime blocks the replication of plus-strand viral RNA by targeting the viral 3A coding region. Enviroxime can be a useful tool for investigating the natural function of the 3A protein .

HY-124806

TTP-8307 2 Publications Verification	Enterovirus DNA/RNA Synthesis HCV	Infection
TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC₅₀=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP) .

HY-124598

MRL-1237	Enterovirus	Infection
MRL-1237 is an inhibitor of the replication of several *enteroviruses* targeting the non-structural protein 2C of the virus. MRL-1237 shows effective inhibition against poliovirus and various other enteroviruses. MRL-1237 does not inhibit the NTPase (ATPase) activity of 2C protein. MRL-1237 can be used for the research of infection .

HY-D2898

Jun14157	Fluorescent Dye Enterovirus	Infection
Jun14157 is a fluorescence polarization probe that can specifically bind to the conserved allosteric site of enterovirus 2C proteins (Ex: 485/20; Em: 528/20). Jun14157 has K_d values of 2.3 μM, 1.4 μM, and 1.1 μM for EV-D68 2C, EV-A71 2C, and CVB3 2C, respectively. Jun14157 can be used in research related to enteroviruses .

HY-145850

EV-A71-IN-1	Enterovirus	Infection
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC₅₀ of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC₅₀>56.2 μM) .

HY-113891

JX040	Enterovirus	Infection
JX040 has an antiviral activity against non-polio enteroviruses, while JX040 has a weak antiviral activity against polioviruses .

HY-19952R

Pleconaril (Standard) VP 63843 (Standard); Win 63843 (Standard)	Reference Standards Enterovirus	Infection
Pleconaril (Standard) is the analytical standard of Pleconaril. This product is intended for research and analytical applications. Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. Pleconaril has potential for use in rhinoviruses and enteroviruses research .

HY-175740

Antiviral agent 71	Enterovirus	Infection
Antiviral agent 71 (Compound 26) is an antiviral agent. Antiviral agent 71 has a broad-spectrum enterovirus antiviral activity, such as EV-D68, Echo-11 and HRV-14 with EC₅₀s of 0.017-4.1 μM. EV-D68-IN-1 can be used for non-polio enteroviruses (NPEV) infections research .

HY-170940

Dyrk1A-IN-12	DYRK Enterovirus	Infection
Dyrk1A-IN-12 (compound S43) is a Dyrk (Dual specificity tyrosine phosphorylation regulated kinase 1A inhibitor. Dyrk1A-IN-12 inhibits Dyrk1A with a IC₅₀ of 95 nM. Dyrk1A-IN-12 shows anti-EV-A71 activity with an EC₅₀ of 4.4 μM, CC₅₀ of 12.8 μM and SI of 2.9. Dyrk1A-IN-12 shows potent inhibition against herpes simplex virus (HSV) .

HY-161357

KR-27370	PI4K	Infection
KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC₅₀: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity .

HY-182971

PROTAC EV-A71 Degrader-1	PROTACs Enterovirus	Infection
PROTAC EV-A71 Degrader-1 is a PROTAC degrader targeting EV-A71 3D polymerase, with broad-spectrum activity against a variety of enteroviruses. PROTAC EV-A71 Degrader-1 induces the degradation of EV-A71 3D polymerase through the ubiquitin-proteasome and autophagy-lysosome pathways, and blocks viral replication. PROTAC EV-A71 Degrader-1 protects infected mice from death, alleviates tissue damage, and exhibits safety profiles. PROTAC EV-A71 Degrader-1 can be used in the research of enterovirus infections. (Pink: EV-A71 ligand (HY-19339); Blue: E3 ligase ligand (HY-W012479); Black: linker (HY-W105744)) .

HY-185215

GS-646089	DNA/RNA Synthesis RSV	Infection
GS-646089 is a broad-spectrum antiviral nucleoside analog that exhibits significant inhibitory activity against *respiratory syncytial virus* (RSV), human metapneumovirus (hMPV), rhinovirus** (enterovirus) and enteroviruses. The IC₅₀ of GS-646089 targeting RNA-dependent RNA polymerase (RdRp) ranges from 43 to 46 nM. GS-646089 blocks viral replication by being converted into a triphosphate metabolite intracellularly, which competes with ATP for incorporation into nascent RNA strands and acts as an immediate chain terminator. GS-646089 is the parent compound of the double prodrug GS-7682 (HY-161877), and is used in studies of acute respiratory viral infections and infections caused by related pathogens .

Jun14157	Fluorescent Dyes
Jun14157 is a fluorescence polarization probe that can specifically bind to the conserved allosteric site of enterovirus 2C proteins (Ex: 485/20; Em: 528/20). Jun14157 has K_d values of 2.3 μM, 1.4 μM, and 1.1 μM for EV-D68 2C, EV-A71 2C, and CVB3 2C, respectively. Jun14157 can be used in research related to enteroviruses .

cis-Resveratrol 1 Publications Verification	Infection other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Enterovirus NF-κB
cis-Resveratrol exhibits signifcant antiviral activity. cis-Resveratrol inhibits enteroviruses with IC₅₀s of 12.2 µM and 37.6 µM for coxsackievirus B3 (CVB3) and enterovirus 71 (EV71), respectively. cis-Resveratrol is the inhibitor for NF-κB signaling pathway .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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enteroviruses

Inhibitors & Agonists

Fluorescent Dyes

NaturalProducts

Natural
Products