1. Anti-infection
  2. Enterovirus

Pleconaril (Synonyms: VP 63843; Win 63843)

Cat. No.: HY-19952 Purity: 98.78%
Handling Instructions

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM.

For research use only. We do not sell to patients.
Pleconaril Chemical Structure

Pleconaril Chemical Structure

CAS No. : 153168-05-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
5 mg USD 96 In-stock
10 mg USD 144 In-stock
50 mg USD 540 In-stock
100 mg USD 720 In-stock
200 mg USD 960 In-stock
500 mg   Get quote  
1 g   Get quote  

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Related Small Molecules:

  • Biological Activity

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Description

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM. Target: enterovirus Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections.

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1113 mL 26.2226 mL
5 mM 0.5245 mL 2.6223 mL 5.2445 mL
10 mM 0.2622 mL 1.3111 mL 2.6223 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

381.35

Formula

C₁₈H₁₈F₃N₃O₃

CAS No.

153168-05-9

SMILES

FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Pleconaril
Cat. No.:
HY-19952
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