2. Anti-infection
  3. Enterovirus
  4. Pleconaril

Pleconaril  (Synonyms: VP 63843; Win 63843)

Cat. No.: HY-19952 Purity: 99.96%
COA Handling Instructions

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections.

For research use only. We do not sell to patients.

Pleconaril Chemical Structure

Pleconaril Chemical Structure

CAS No. : 153168-05-9

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 106 In-stock
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Solid
5 mg USD 96 In-stock
10 mg USD 144 In-stock
50 mg USD 540 In-stock
100 mg USD 720 In-stock
200 mg USD 960 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pleconaril:

Pleconaril Related Antibodies

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Description

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM. Target: enterovirus Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections.

Clinical Trial
Molecular Weight

381.35

Appearance

Solid

Formula

C18H18F3N3O3
CAS No.
SMILES

FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (262.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1113 mL 26.2226 mL
5 mM 0.5245 mL 2.6223 mL 5.2445 mL
10 mM 0.2622 mL 1.3111 mL 2.6223 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (245 KB) LCMS (119 KB)

Handling Instructions (2659 KB)
References
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Pleconaril Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pleconaril153168-05-9VP 63843 Win 63843VP63843VP-63843Win63843Win 63843Win-63843EnterovirusRhinovirusHRVHRVsHEVHEVsInhibitorinhibitorinhibit

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