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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
eukaryotic initiation factor 4e
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "eukaryotic initiation factor 4e" in MCE Product Catalog:
Research Areas:
eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e) with an IC50 of 13 nM. eIF4E-IN-2 inhibits MDA-MB-361 cells proliferation. eIF4E-IN-2 can be used for the study of breast cancer .
Cat. No.: HY-16366
CAS No.: 865783-99-9
Synonyms: ON 014185
Research Areas:
Briciclib (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib can be used for the study of hematological system tumors and solid tumors .
Cat. No.: HY-W348485
CAS No.: 899937-47-4
WRX606 is an orally active nonrapalog inhibitor for mTOR complex 1 (mTORC1M). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (S6K1) (IC50 = 10 nM) and eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC50 = 0.27 μM) in MCF-7 cells. WRX606 suppresses tumor growth in mice without promotion of metastasis. WRX606 can be studied in research as an antitumor agent .
Cat. No.: HY-145309
CAS No.: 2573979-29-8
Research Areas:
eIF4E-IN-3 (Example 485) is a eIF4E inhibitor with an IC50 of 0.00859 μM. eIF4E-IN-3 inhibits the activity of eIF4E. eIF4E-IN-3 is used in cancer research .
Cat. No.: HY-148664
CAS No.: 1373822-39-9
Research Areas:
eIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical
activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .
Cat. No.: HY-184004
Research Areas:
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma .
Cat. No.: HY-168326
CAS No.: 1139263-21-0
Target:
Research Areas:
Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM .
Cat. No.: HY-183328
Target:
Research Areas:
MNK1/2-IN-11 is a potent, selective and orally active MNK1/2 inhibitor with MNK1 IC50 of 1.2 nM, MNK2 IC50 of 1.3 nM. MNK1/2-IN-11 reduces eukaryotic translation initiation factor 4E phosphorylation, decreases Mcl-1 and Cyclin D1 expression. MNK1/2-IN-11 inhibits tumor growth in mouse CT26 colorectal tumor models. MNK1/2-IN-11 can be used for the research of colorectal cancer .
Cat. No.: HY-P85623
Synonyms: 4e BP3; 4e-BP3; 4eBP3; eIF4e binding protein 3; eukaryotic initiation factor 4e binding protein 3; eukaryotic translation initiation factor 4e binding protein 3; OTTHUMP00000159879.
Cat. No.: HY-155676
Research Areas:
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .
Cat. No.: HY-16366A
CAS No.: 865784-01-6
Synonyms: ON 014185 sodium
Research Areas:
Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors .
Cat. No.: HY-P70152
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: EIF4e; EIF-4F 25 KDa Subunit; Prev. EIF4eL1; eukaryotic Translation initiation factor 4e-Like 1; Prev. EIF4F; AUTS19; EIF4e1; CBP; MRNA Cap-Binding Protein; eukaryotic Translation initiation factor 4e; EIF-4e
Cat. No.: HY-P703422
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF4e; EIF-4F 25 KDa Subunit; Prev. EIF4eL1; eukaryotic Translation initiation factor 4e-Like 1; Prev. EIF4F; AUTS19; EIF4e1; CBP; MRNA Cap-Binding Protein; eukaryotic Translation initiation factor 4e; EIF-4e
Cat. No.: HY-P70415
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF4eBP1; eukaryotic Translation initiation factor 4e-Binding Protein 1; eukaryotic Translation initiation factor 4e Binding Protein 1; EIF4e-Binding Protein 1; PHAS-I; 4eBP1; 4e-BP1; BP-1; Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin
Cat. No.: HY-P70416
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF4eBP2; EIF4eBP2 Protein; eukaryotic Translation initiation factor 4e Binding Protein 2; PHASII; eukaryotic Translation initiation factor 4e-Binding Protein 2; 4e-BP2; EIF4e-Binding Protein 2; 4eBP2; Phosphorylated, Heat And Acid Stable Regulated By Ins
Cat. No.: HY-P85622
Synonyms: 4e-BP2; 4eBP2; 4eBP2_HUMAN; eIF4e binding protein 2; eIF4e-binding protein 2; Eif4ebp2; eukaryotic translation initiation factor 4e binding protein 1; eukaryotic translation initiation factor 4e-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
