865784-01-6
Chemical Structure
Briciclib sodium
Synonym(s): ON 014185 sodium
- CAS No.: 865784-01-6
- Formula:C19H21Na2O10PS
- Molecular Weight:518.38
IUPAC Name: sodium (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl phosphate
InChIKey: MIBWXNAYNGADJD-MIIBGCIDSA-L
SMILES: O=S(CC1=CC(OP(O[Na])(O[Na])=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O
Biological Activity: Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors[1].
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Briciclib sodium | Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors. | |||||||||||||||||||||
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Keywords
