eIF4EBP3 Antibody (YA5315)
(Synonyms: 4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; Eukaryotic initiation factor 4E binding protein 3; Eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879.)eIF4EBP3 Antibody (YA5315) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4EBP3.
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Host:
Mouse
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Application:
WB
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Reactivity :
Transfected
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
eIF4EBP3 Antibody (YA5315) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4EBP3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityTransfected
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Observed Molecular WeightObserved band size: 11 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Recombinant protein of human EIF4EBP3.
Transfected
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
eIF4EBP3 is a Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export[1].
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_specificity:The gene is expressed at the highest levels in skeletal muscle, heart, kidneys, and pancreas, but at very low levels in the brain and thymus. -
Subunit
Interacts with EIF4E (PubMed:9593750). Interacts with RPA2 (in unphosphorylated form via N-terminus); the interaction enhances EIF4EBP3-mediated inhibition of EIF4E-mediated mRNA nuclear export (PubMed:22684010)
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SwissProt ID
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Synonyms
4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; Eukaryotic initiation factor 4E binding protein 3; Eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879.
Documentation
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