4 Results for "

guggulsterone e

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "guggulsterone e" in MCE Product Catalog:

22
Guggulsterone
Guggulsterone
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22 Cited Publications
Cat. No.: HY-107738
CAS No.: 95975-55-6
Purity:  99.81%
Synonyms: Z/E-guggulsterone
Category:  

Triterpenes Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .
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(-)-(E)-Guggulsterone
(-)-(E)-Guggulsterone
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Cat. No.: HY-N7781
CAS No.: 39025-24-6
Synonyms: (E)-guggulsterone
Category:  

Commiphora myrrha (Nees) Engl. Metabolic Disease Plants Burseraceae Disease Research Fields Steroids

Target:  

FXR Keap1-Nrf2 Heme Oxygenase (HO) Dengue Virus Bacterial Reactive Oxygen Species (ROS) Estrogen Receptor/ERR Cytochrome P450 Drug Metabolite

(-)-(E)-Guggulsterone ((E)-Guggulsterone) is an orally active natural stereoisomer of Guggulsterone (HY-107738). (-)-(E)-Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-)-(E)-Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-)-(E)-Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-)-(E)-Guggulsterone has cardiac protective and antioxidant activities in rats .
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Guggulsterone (Standard)
Guggulsterone (Standard)
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Cat. No.: HY-107738R
CAS No.: 95975-55-6
Synonyms: Z/E-guggulsterone (Standard)
Category:  

Triterpenes Terpenoids Plants Burseraceae Commiphora wightii

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards

Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.
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(-)-(E)-Guggulsterone (Standard)
(-)-(E)-Guggulsterone (Standard)
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Cat. No.: HY-N7781R
CAS No.: 39025-24-6
Synonyms: (E)-guggulsterone (Standard)
Category:  

Commiphora myrrha (Nees) Engl. Metabolic Disease Plants Burseraceae Disease Research Fields Steroids

Target:  

Reference Standards Drug Metabolite FXR Keap1-Nrf2 Heme Oxygenase (HO) Dengue Virus Bacterial Reactive Oxygen Species (ROS) Estrogen Receptor/ERR Cytochrome P450

(-)-(E) -guggulsterone (Standard) is the analytical standard for (-)-(E) -guggulsterone ((E)-Guggulsterone) (HY-N7781). (-)-(E)-Guggulsterone is an orally active natural stereoisomer of Guggulsterone (HY-107738). (-)-(E)-Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-)-(E)-Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-)-(E)-Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-)-(E)-Guggulsterone has cardiac protective and antioxidant activities in rats.
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