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Results for "

hm2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GPR109A (1) Adrenergic Receptor (2) Apoptosis (1) DNA/RNA Synthesis (1) Drug Isomer (1) Herbicide (1) Histamine Receptor (2) mAChR (8) Protoporphyrinogen IX oxidase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Sirtuin (1) Small Interfering RNA (siRNA) (1) SOD (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (7) Neurological Disease (4)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Targets Recommended: GPR109A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17585

Mepenzolate bromide 5+ Cited Publications	mAChR GPR109A	Others Inflammation/Immunology
Mepenzolate bromide is an orally administered muscarinic receptor antagonist with K_is of 0.68 and 2.6 nM for *hM2R* and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome .Mepenzolate bromide is a GPR109A inhibitor ^[2].

HY-N0340

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	mAChR	Neurological Disease Inflammation/Immunology
Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (K_i 83 nmol/L), *hM2* (K_i 233 nmol/L), rat intestinal M3 (K_i 290 nmol/L) and hM3 (K_i 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer ^[2].

HY-12980

Batefenterol GSK961081; TD-5959	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and *β₂-adrenoceptor* agonist; displays high affinity for hM2, hM3 muscarinic and hβ₂-adrenoceptor with K_i values of 1.4, 1.3 and 3.7 nM, respectively.

HY-U00302

CHF5407	mAChR	Inflammation/Immunology
CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity .

HY-12980R

Batefenterol (Standard) GSK961081 (Standard); TD-5959 (Standard)	Adrenergic Receptor mAChR Reference Standards	Inflammation/Immunology Endocrinology
Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

HY-14845

Levomequitazine (S)-Mequitazine	Drug Isomer Histamine Receptor	Inflammation/Immunology
Levomequitazine (Compound V0114) ((S)-Mequitazine), the levorotatory enantiomer of Mequitazine (HY-B2168), is an orally active, inverse H4 receptor agonist (IC₅₀s: 94 nM (hM2), 17 nM (hM3)). Levomequitazine strongly binds to human histamine H4 receptor. Levomequitazine antagonizes the activating action induced by histamine on H4 receptor. Levomequitazine induces a powerful and statistically significant anti-inflammatory effect. Levomequitazine can be used for research on inflammatory diseases .

HY-N0340R

Scopolamine butylbromide (Standard) Hyoscine butylbromide (Standard); (-)-Scopolamine butylbromide (Standard); Butylscopolamine bromide (Standard)	Reference Standards mAChR	Neurological Disease Inflammation/Immunology
Scopolamine butylbromide (Standard) is the analytical standard of Scopolamine butylbromide (HY-N0340). This product is intended for research and analytical applications. Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (K_i 83 nmol/L), *hM2* (K_i 233 nmol/L), rat intestinal M3 (K_i 290 nmol/L) and hM3 (K_i 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer ^[2].

HY-RS02661

CHRM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CHRM2 Human Pre-designed siRNA Set A contains three designed siRNAs for CHRM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHRM2 Human Pre-designed siRNA Set A CHRM2 Human Pre-designed siRNA Set A

HY-183853

Arecaidine-propargyl ester	mAChR Reactive Oxygen Species (ROS) DNA/RNA Synthesis Apoptosis SOD Sirtuin	Cardiovascular Disease Neurological Disease Cancer
Arecaidine-propargyl ester is a selective M2 muscarinic receptor agonist with blood-brain barrier permeability, with a pK_i of 5.91 for hm1, 7.06 for hm2, 6.07 for hm3, 6.01 for hm4, and 6.03 for hm5. Arecaidine-propargyl ester stimulates central and peripheral muscarinic receptors. Arecaidine-propargyl ester increases intracellular ROS, induces DNA damage and Apoptosis, and upregulates the expression of MnSOD and SIRT1. Arecaidine-propargyl ester reduces sympathetic nerve outflow, induces dose-dependent hypotension, and triggers negative chronotropic effects at high peripheral doses. Arecaidine-propargyl ester can be used in research related to Alzheimer's disease and glioblastoma ^[2] .

HY-170444

ADS1017	Histamine Receptor mAChR	Neurological Disease
ADS1017 is the antagonist for histamine receptor and muscarinic receptor, that exhibits good affinities to hH3R, hH4R, hM2R and hM4R with pK_i of 6.8, 5.5, 7.4 and 7.2. ADS1017 exhibits analgesic and anti-allodynic efficacy in mice Capsaicin (HY-10448)-or Oxaliplatin (HY-17371)-induced pain models .

HY-172151

PPO-IN-17	Herbicide Protoporphyrinogen IX oxidase	Others
PPO-IN-17 (Compound 6R) is the inhibitor protoporphyrinogen IX oxidase (PPO) that inhibits Nicotiana tobacco PPO (NtPPO) with K_i of 30.34 nM. PPO-IN-17 exhibits herbicidal activity that inhibits barnyardgrass (E. crus-galli), foxtail grass (D. sanguinalis), alfalfa (M. sativa) and Canada cocklebur (C. canadensis) (>95% inhibition rate at a concentration of 37.5 g/hm ²). PPO-IN-17 exhibits no toxicity on rice (at a concentration of 75 g/hm ²) or on honeybees (at a concentration of 6400 mg/kg) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0340

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	Alkaloids Structural Classification Other Alkaloids Datura metel L. Solanaceae Plants Source Classification	mAChR
Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (K_i 83 nmol/L), *hM2* (K_i 233 nmol/L), rat intestinal M3 (K_i 290 nmol/L) and hM3 (K_i 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer ^[2].

HY-N0340R

Scopolamine butylbromide (Standard) Hyoscine butylbromide (Standard); (-)-Scopolamine butylbromide (Standard); Butylscopolamine bromide (Standard)	Alkaloids Structural Classification Other Alkaloids Datura metel L. Solanaceae Plants Source Classification	Reference Standards mAChR
Scopolamine butylbromide (Standard) is the analytical standard of Scopolamine butylbromide (HY-N0340). This product is intended for research and analytical applications. Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (K_i 83 nmol/L), *hM2* (K_i 233 nmol/L), rat intestinal M3 (K_i 290 nmol/L) and hM3 (K_i 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer ^[2].

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82865

	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) CHRM2; hm2; AChR; Acm2	WB, IHC-P, IP	Human, Mouse, Rat
	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Muscarinic Acetylcholine Receptor M2.

HY-P810638

	Muscarinic Acetylcholine Receptor 2 Antibody (YA9900) CHRM2; hm2; AChR; Acm2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Muscarinic Acetylcholine Receptor 2 Antibody (YA9900) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Muscarinic Acetylcholine Receptor 2.

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Cat. No.	Product Name		Classification

HY-183853

Arecaidine-propargyl ester		Alkynes
Arecaidine-propargyl ester is a selective M2 muscarinic receptor agonist with blood-brain barrier permeability, with a pK_i of 5.91 for hm1, 7.06 for hm2, 6.07 for hm3, 6.01 for hm4, and 6.03 for hm5. Arecaidine-propargyl ester stimulates central and peripheral muscarinic receptors. Arecaidine-propargyl ester increases intracellular ROS, induces DNA damage and Apoptosis, and upregulates the expression of MnSOD and SIRT1. Arecaidine-propargyl ester reduces sympathetic nerve outflow, induces dose-dependent hypotension, and triggers negative chronotropic effects at high peripheral doses. Arecaidine-propargyl ester can be used in research related to Alzheimer's disease and glioblastoma ^[2] .

CHRM2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CHRM2 Human Pre-designed siRNA Set A contains three designed siRNAs for CHRM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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