76-90-4
76-90-4
Chemical Structure
Mepenzolate bromide
- CAS No.: 76-90-4
- Formula:C21H26BrNO3
- Molecular Weight:420.34
IUPAC Name: 3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-ium bromide
InChIKey: JRRNZNSGDSFFIR-UHFFFAOYSA-M
SMILES: C[N+]1(C)CC(OC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=O)CCC1.[Br-]
Biological Activity: Mepenzolate bromide is an orally administered muscarinic receptor antagonist with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome[1].Mepenzolate bromide is a GPR109A inhibitor[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mepenzolate bromide | 99.91% | Mepenzolate bromide is an orally administered muscarinic receptor antagonist with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome.Mepenzolate bromide is a GPR109A inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-B0953APipenzolate bromide -
Similarity Score 0.84
HY-105771Parapenzolate bromide -
Similarity Score 0.78
HY-B1132Clidinium bromide -
Similarity Score 0.71
HY-105790APiperilate hydrochloride -
Similarity Score 0.70
HY-105790Piperilate -
Similarity Score 0.70
HY-106564AFlutropium bromide -
Similarity Score 0.70
HY-U00405Bronchospasmolytic agent 1 -
Similarity Score 0.69
HY-B0461RTrospium chloride (Standard) -
Similarity Score 0.68
HY-131634Difemerine hydrochloride -
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References
- [1]. Yasunobu Yamashita,et al.Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities. Bioorg Med Chem. 2014 Jul 1;22(13):3488-97. [Content Brief]
- [2]. Hesham Aly Salem, et al. Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis. Sci Rep. 2017 Aug 2;7(1):7139. [Content Brief]
