76-90-4
Chemical Structure
Mepenzolate bromide
- CAS No.: 76-90-4
- Formula:C21H26BrNO3
- Molecular Weight:420.34
IUPAC Name: 3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-ium bromide
InChIKey: JRRNZNSGDSFFIR-UHFFFAOYSA-M
SMILES: C[N+]1(C)CC(OC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=O)CCC1.[Br-]
Biological Activity: Mepenzolate bromide is an orally administered muscarinic receptor antagonist with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome[1].Mepenzolate bromide is a GPR109A inhibitor[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mepenzolate bromide | 99.91% | Mepenzolate bromide is an orally administered muscarinic receptor antagonist with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome.Mepenzolate bromide is a GPR109A inhibitor. | ||||||||||||||||||||
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- [1]. Yasunobu Yamashita,et al.Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities. Bioorg Med Chem. 2014 Jul 1;22(13):3488-97. [Content Brief]
- [2]. Hesham Aly Salem, et al. Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis. Sci Rep. 2017 Aug 2;7(1):7139. [Content Brief]
Keywords
