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Results for "

human DPP-IV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Dipeptidyl Peptidase (21) Ferroptosis (7) GLP Receptor (4) Glycosidase (1) GPR119 (1) Isotope-Labeled Compounds (4) P-glycoprotein (2) Reference Standards (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (19)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14291

Vildagliptin 5 Publications Verification LAF237; NVP-LAF 237	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-145779

H-Glu(Met-OH)-OH H-γ-Glu-Met-OH; γ-Glu-Met	Dipeptidyl Peptidase	Metabolic Disease
H-Glu(Met-OH)-OH (H-γ-Glu-Met-OH; γ-Glu-Met) is a DPP-IV inhibitor with an IC₅₀ of 2.11 mM. H-Glu(Met-OH)-OH binds to DPP-IV’s active site to block substrate binding. H-Glu(Met-OH)-OH can be used for the research of type 2 diabetes .

HY-14292

NVP-DPP728	Dipeptidyl Peptidase	Metabolic Disease
NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a K_i of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .

HY-P1230

HAEGT	Dipeptidyl Peptidase GLP Receptor	Metabolic Disease
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human *dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala* is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .

HY-14291A

Vildagliptin dihydrate LAF237 dihydrate; NVP-LAF 237 dihydrate	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S1

Vildagliptin-d7 LAF237-d₇; NVP-LAF 237-d₇	Isotope-Labeled Compounds Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin-d₇ is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S

Vildagliptin-d3 LAF237-d₃; NVP-LAF 237-d₃	Isotope-Labeled Compounds Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin-d₃ is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291R

Vildagliptin (Standard) LAF237 (Standard); NVP-LAF 237 (Standard)	Reference Standards Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S2

Vildagliptin-13C5,15N LAF237-¹³C₅,¹⁵N; NVP-LAF 237-¹³C₅,¹⁵N	Isotope-Labeled Compounds Dipeptidyl Peptidase Apoptosis Ferroptosis	Metabolic Disease
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-169724

RBx-0597	Dipeptidyl Peptidase	Metabolic Disease
RBx-0597 is a potent and selective *DPP-IV* inhibitor, demonstrating IC₅₀ values of 32, 31, and 39 nM against human, mouse, and rat plasma *DPP-IV*, respectively. RBx-0597 shows potential for type 2 diabetes research .

HY-U00346A

TS-021	Dipeptidyl Peptidase	Metabolic Disease
TS-021 is a selective，orally active，reversible and long-acting *DPP-IV* inhibitor，and exhibits significant inhibition selectivity against DPP-8 (> 600 fold)，DPP-9 (> 1200 fold) and other peptidases (> 15,000 fold). TS-021 inhibits DPP-IV activity in human plasma with an IC₅₀ value of 5.34 nM. TS-021 has long-term persistent plasma drug concentration and potent antihyperglycemic activity，and increases in the active form of GLP-1 .

HY-111150

AMG-222	Dipeptidyl Peptidase	Metabolic Disease
AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to *DPPIV. AMG 222 binds to human* plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes .

HY-14291B

(2R)-Vildagliptin (2R)-LAF237; (2R)-NVP-LAF 237	Dipeptidyl Peptidase	Metabolic Disease
(2R)-Vildagliptin is the isomer of Vildagliptin (HY-14291), and can be used as an experimental control. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S5

Vildagliptin-d6 LAF237-d₆ ; NVP-LAF 237-d₆	Isotope-Labeled Compounds Apoptosis Ferroptosis Dipeptidyl Peptidase	Metabolic Disease Cancer
Vildagliptin-d₆ (LAF237-d₆ ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-10289

Carmegliptin RO-4876904	Dipeptidyl Peptidase GLP Receptor P-glycoprotein	Metabolic Disease
Carmegliptin (RO-4876904) is an orally active and potent *DPP IV* inhibitor with a human DPP IV IC₅₀ of 6.8 nM. Carmegliptin binds to the S1 pocket of DPP IV, blocks the degradation of GLP 1, potentiates endogenous GLP 1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin acts as a substrate for human P glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin can be used for the research of type 2 diabetes, non insulin dependent diabetes mellitus .

HY-109060

Garvagliptin ZYDPLA1	Dipeptidyl Peptidase	Metabolic Disease
Garvagliptin (ZYDPLA1) is an orally active, competitive and long acting *DPP4* Inhibitor, with an IC₅₀ of 2.99 nM against human recombinant DPP IV. Garvagliptin (ZYDPLA1) exhibits antihyperglycemic effect .

HY-10289A

Carmegliptin hydrochloride RO-4876904 hydrochloride	Dipeptidyl Peptidase GLP Receptor P-glycoprotein	Metabolic Disease
Carmegliptin hydrochloride (RO-4876904 hydrochloride) is an orally active and potent *DPP‑IV* inhibitor with a human DPP‑IV IC₅₀ of 6.8 nM. Carmegliptin hydrochloride binds to the S1 pocket of DPP‑IV, blocks the degradation of GLP‑1, potentiates endogenous GLP‑1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin hydrochloride acts as a substrate for human P‑glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin hydrochloride can be used for the research of type 2 diabetes, non‑insulin‑dependent diabetes mellitus .

HY-N17777

Cyclocarin A	Dipeptidyl Peptidase Glycosidase	Others
Cyclocarin A is a triterpenoid compound that can be isolated from the leaves of Cyclocarya paliurus. Cyclocarin A shows only weak inhibitory activity against α-glucosidase, lipase, DPP-IV, aldose reductase, and human cancer cell lines (IC₅₀>10 μM) .

HY-182300

FE 999011	Dipeptidyl Peptidase GLP Receptor	Metabolic Disease
FE 999011 is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with IC₅₀ values of 7 nM and 3 nM against human and rat sources, respectively. FE 999011 acts as a glucose tolerance-improving agent and a GLP-1 receptor activator, which reduces blood glucose fluctuation, promotes GLP-1 release and decreases the insulin-glucose ratio. FE 999011 regulates lipid metabolism, delays the onset of diabetes, stabilizes food and water intake, reduces hypertriglyceridemia, prevents the elevation of free fatty acids, and delays the progression of impaired glucose tolerance to disease. FE 999011 can be used in relevant studies of type 2 diabetes .

HY-N17532

(Rac)-Regaloside D	Dipeptidyl Peptidase	Others
(Rac)-Regaloside D is a phenylpropanoid. (Rac)-Regaloside D can be found in the scaly bulbs of Lilium longiflorum. (Rac)-Regaloside D does not exhibit dipeptidyl peptidase IV (DPP-IV) inhibitory activity in vitro .

HY-182580

HBK001	GPR119 Dipeptidyl Peptidase	Metabolic Disease Inflammation/Immunology
HBK001 is an orally active and selective dual GPR119 agonist and DPP-IV inhibitor. HBK001 triggers cAMP production, PKA activation, CREB phosphorylation, glucose-stimulated insulin secretion, plasma incretin elevation, β-cell proliferation, and β-cell function gene up-regulation. HBK001 reduces blood glucose, ameliorates hyperglycemia, improves glucose tolerance, and enhances islet morphology. HBK001 can be used for the research of type 2 diabetes mellitus .

Cat. No.	Product Name	Target	Research Area

HY-145779

H-Glu(Met-OH)-OH H-γ-Glu-Met-OH; γ-Glu-Met	Dipeptidyl Peptidase	Metabolic Disease
H-Glu(Met-OH)-OH (H-γ-Glu-Met-OH; γ-Glu-Met) is a DPP-IV inhibitor with an IC₅₀ of 2.11 mM. H-Glu(Met-OH)-OH binds to DPP-IV’s active site to block substrate binding. H-Glu(Met-OH)-OH can be used for the research of type 2 diabetes .

HY-P1230

HAEGT	Dipeptidyl Peptidase GLP Receptor	Metabolic Disease
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human *dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala* is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N17777

Cyclocarin A	Triterpenes Structural Classification Juglandaceae Terpenoids Cyclocarya paliurus (Batal.) Iljinsk. Plants Source Classification	Dipeptidyl Peptidase Glycosidase
Cyclocarin A is a triterpenoid compound that can be isolated from the leaves of Cyclocarya paliurus. Cyclocarin A shows only weak inhibitory activity against α-glucosidase, lipase, DPP-IV, aldose reductase, and human cancer cell lines (IC₅₀>10 μM) .

HY-N17532

(Rac)-Regaloside D	Structural Classification Monophenols Liliaceae Lilium longiflorum Thunb. Phenols Plants Source Classification	Dipeptidyl Peptidase
(Rac)-Regaloside D is a phenylpropanoid. (Rac)-Regaloside D can be found in the scaly bulbs of Lilium longiflorum. (Rac)-Regaloside D does not exhibit dipeptidyl peptidase IV (DPP-IV) inhibitory activity in vitro .

Species:	Human (10)
Tag:	His (6) Tag Free (1) Avi (2) Fc (3)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72975

	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293) 4 Publications Verification Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4	Human	HEK293
	The CD26/dipeptidyl peptidase 4 protein is a cell surface glycoprotein receptor that induces T cell proliferation and NF-kappa-B activation. CD26 also works with FAP to promote pericellular proteolysis, endothelial cell migration, and invasion of the extracellular matrix. CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293) is the recombinant human-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with tag free.

HY-P72976

	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc) Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4	Human	HEK293
	The CD26/dipeptidyl peptidase 4 protein is a cell surface glycoprotein receptor that induces T cell proliferation and NF-kappa-B activation. CD26 also works with FAP to promote pericellular proteolysis, endothelial cell migration, and invasion of the extracellular matrix. CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc) is the recombinant human-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P704585

	FAP Protein, Human (HEK293, hFc) Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (HEK293, hFc) is the recombinant human-derived FAP protein, expressed by HEK293, with N-hFc labeled tag.

HY-P705417

	CD26/Dipeptidyl Peptidase 4 Protein, Human (Biotinylated, HEK293, His-Avi) Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4	Human	HEK293

HY-P72659A

	FAP Protein, Human (HEK293, N-His) 2 Publications Verification Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (HEK293, His) is the recombinant human-derived FAP protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P77521

	FAP Protein, Human (Biotinylated, HEK293, His) Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived FAP protein, expressed by HEK293 , with N-His labeled tag.

HY-P78121

	FAP Protein, Human (Biotinylated, HEK293, His-Avi) FAP; FAPalpha; SIMP; Seprase; APCE; DPPIV; DPPIVA; FAPA	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FAP protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P704586

	FITC-Labeled FAP Protein, Human (HEK293, hFc) Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FITC-Labeled FAP Protein, Human (HEK293, hFc) is the recombinant human-derived FITC-Labeled FAP protein, expressed by HEK293, with N-hFc labeled tag.

HY-P704587

	FITC-Labeled FAP Protein, Human (HEK293, His) Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FITC-Labeled FAP Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled FAP protein, expressed by HEK293, with N-His labeled tag.

HY-P70017

	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His) rHuDipeptidyl peptidase 4/CD26, His; Dipeptidyl peptidase 4; ADABP; Adenosine deaminase complexing protein 2; ADCP-2; Dipeptidyl peptidase IV; DPP IV; T-cell actIVation antigen CD26	Human	HEK293
	The CD26/dipeptidyl peptidase 4 protein is a cell surface glycoprotein receptor that induces T cell proliferation and NF-kappa-B activation. CD26 also works with FAP to promote pericellular proteolysis, endothelial cell migration, and invasion of the extracellular matrix. CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His) is the recombinant human-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14291S1

Vildagliptin-d7
Vildagliptin-d₇ is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S

Vildagliptin-d3
Vildagliptin-d₃ is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S2

Vildagliptin-13C5,15N
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S5

Vildagliptin-d6
Vildagliptin-d₆ (LAF237-d₆ ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2) Biotin (3)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86673

	FAP Antibody (YA6365) Prolyl endopeptidase FAP; FAPA; Fibroblast actIVation protein, alpha; 170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; Fibroblast actIVation protein alpha; Integral membrane serine protease; SEPR_human; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; Antiplasmin-cleaving enzyme FAP, soluble form; APCE.	WB	Human
	FAP Antibody (YA6365) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAP.

HY-P86673A

	FAP Antibody (YA6365)(PBS only) Prolyl endopeptidase FAP; FAPA; Fibroblast actIVation protein, alpha; 170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; Fibroblast actIVation protein alpha; Integral membrane serine protease; SEPR_human; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; Antiplasmin-cleaving enzyme FAP, soluble form; APCE.	WB	Human
	FAP Antibody (YA6365) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAP.

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human DPP-IV

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
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