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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
human DPP-IV
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "human DPP-IV" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: LAF237; NVP-LAF 237
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Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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2
2 Cited Publications
Cat. No.: HY-P72659A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha
Cat. No.: HY-145779
CAS No.: 17663-87-5
Synonyms: H-γ-Glu-Met-OH; γ-Glu-Met
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Cat. No.: HY-14292
CAS No.: 247016-69-9
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NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .
Cat. No.: HY-P1230
CAS No.: 852155-81-8
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Cat. No.: HY-14291A
CAS No.: 2133364-01-7
Synonyms: LAF237 dihydrate; NVP-LAF 237 dihydrate
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Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity .
Cat. No.: HY-14291S1
CAS No.: 1133208-42-0
Synonyms: LAF237-d7; NVP-LAF 237-d7
Cat. No.: HY-14291S
CAS No.: 1217546-82-1
Synonyms: LAF237-d3; NVP-LAF 237-d3
Cat. No.: HY-14291R
CAS No.: 274901-16-5
Synonyms: LAF237 (Standard); NVP-LAF 237 (Standard)
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Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
Cat. No.: HY-14291S2
CAS No.: 1044741-01-6
Synonyms: LAF237-13C5,15N; NVP-LAF 237-13C5,15N
Cat. No.: HY-169724
CAS No.: 929105-33-9
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RBx-0597 is a potent and selective DPP-IV inhibitor, demonstrating IC50 values of 32, 31, and 39 nM against human, mouse, and rat plasma DPP-IV, respectively. RBx-0597 shows potential for type 2 diabetes research .
Cat. No.: HY-U00346A
CAS No.: 667865-69-2
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TS-021 is a selective，orally active，reversible and long-acting DPP-IV inhibitor，and exhibits significant inhibition selectivity against DPP-8 (> 600 fold)，DPP-9 (> 1200 fold) and other peptidases (> 15,000 fold). TS-021 inhibits DPP-IV activity in human plasma with an IC50 value of 5.34 nM. TS-021 has long-term persistent plasma drug concentration and potent antihyperglycemic activity，and increases in the active form of GLP-1 .
Cat. No.: HY-111150
CAS No.: 913978-37-7
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AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes .
Cat. No.: HY-14291B
CAS No.: 1036959-27-9
Synonyms: (2R)-LAF237; (2R)-NVP-LAF 237
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(2R)-Vildagliptin is the isomer of Vildagliptin (HY-14291), and can be used as an experimental control. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
Cat. No.: HY-14291S5
Synonyms: LAF237-d6 ; NVP-LAF 237-d6
Cat. No.: HY-10289
CAS No.: 813452-18-5
Synonyms: RO-4876904
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Carmegliptin (RO-4876904) is an orally active and potent DPP IV inhibitor with a human DPP IV IC50 of 6.8 nM. Carmegliptin binds to the S1 pocket of DPP IV, blocks the degradation of GLP 1, potentiates endogenous GLP 1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin acts as a substrate for human P glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin can be used for the research of type 2 diabetes, non insulin dependent diabetes mellitus .
Cat. No.: HY-109060
CAS No.: 1601479-87-1
Synonyms: ZYDPLA1
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Garvagliptin (ZYDPLA1) is an orally active, competitive and long acting DPP4 Inhibitor, with an IC50 of 2.99 nM against human recombinant DPP IV. Garvagliptin (ZYDPLA1) exhibits antihyperglycemic effect .
Cat. No.: HY-10289A
CAS No.: 813452-14-1
Synonyms: RO-4876904 hydrochloride
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Carmegliptin hydrochloride (RO-4876904 hydrochloride) is an orally active and potent DPP‑IV inhibitor with a human DPP‑IV IC50 of 6.8 nM. Carmegliptin hydrochloride binds to the S1 pocket of DPP‑IV, blocks the degradation of GLP‑1, potentiates endogenous GLP‑1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin hydrochloride acts as a substrate for human P‑glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin hydrochloride can be used for the research of type 2 diabetes, non‑insulin‑dependent diabetes mellitus .
Cat. No.: HY-N17777
CAS No.: 1403937-45-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
