2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. H-Glu(Met-OH)-OH

H-Glu(Met-OH)-OH  (Synonyms: H-γ-Glu-Met-OH; γ-Glu-Met)

Cat. No.: HY-145779 Purity: 99.63%
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H-Glu(Met-OH)-OH (H-γ-Glu-Met-OH; γ-Glu-Met) is a DPP-IV inhibitor with an IC50 of 2.11 mM. H-Glu(Met-OH)-OH binds to DPP-IV’s active site to block substrate binding. H-Glu(Met-OH)-OH can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

H-Glu(Met-OH)-OH

H-Glu(Met-OH)-OH Chemical Structure

CAS No. : 17663-87-5

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Based on 1 publication(s) in Google Scholar

Other Forms of H-Glu(Met-OH)-OH:

H-Glu(Met-OH)-OH Related Antibodies

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View All Dipeptidyl Peptidase Isoform Specific Products:

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • Biological Activity

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Description

H-Glu(Met-OH)-OH (H-γ-Glu-Met-OH; γ-Glu-Met) is a DPP-IV inhibitor with an IC50 of 2.11 mM. H-Glu(Met-OH)-OH binds to DPP-IV’s active site to block substrate binding. H-Glu(Met-OH)-OH can be used for the research of type 2 diabetes[1].

IC50 & Target[1]

DPP-4

2.11 mM (IC50)

In Vitro

H-Glu(Met-OH)-OH (0.0125-2.5 mg/mL; 30 mins) potently inhibits human DPP-IV in a competitive manner with an IC50 of 2.11 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

H-Glu(Met-OH)-OH Related Antibodies
Molecular Weight

278.33

Formula

C10H18N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (35.93 mM; Need ultrasonic)

DMSO : 5 mg/mL (17.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5929 mL 17.9643 mL 35.9286 mL
5 mM 0.7186 mL 3.5929 mL 7.1857 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.5929 mL 17.9643 mL 35.9286 mL 89.8214 mL
5 mM 0.7186 mL 3.5929 mL 7.1857 mL 17.9643 mL
10 mM 0.3593 mL 1.7964 mL 3.5929 mL 8.9821 mL
15 mM 0.2395 mL 1.1976 mL 2.3952 mL 5.9881 mL
H2O 20 mM 0.1796 mL 0.8982 mL 1.7964 mL 4.4911 mL
25 mM 0.1437 mL 0.7186 mL 1.4371 mL 3.5929 mL
30 mM 0.1198 mL 0.5988 mL 1.1976 mL 2.9940 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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H-Glu(Met-OH)-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Glu(Met-OH)-OH17663-87-5H-γ-Glu-Met-OH γ-Glu-MetDipeptidyl PeptidaseDPPhuman DPP-IVcalcium-sensing receptorglutathione metabolismhydroxyl radicalBacillus amyloliquefaciens L-glutaminasetype 2 diabetes mellitusInhibitorinhibitorinhibit

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