913978-37-7
Chemical Structure
AMG-222
- CAS No.: 913978-37-7
- Formula:C32H39N9O3
- Molecular Weight:597.71
IUPAC Name: 5-((S)-2-((2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)propyl)-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-10,11-dihydro-5H-dibenzo[a,d][7]annulene-2,8-dicarboxamide
InChIKey: NVSWJKWHLUTHLP-CPJSRVTESA-N
SMILES: O=C(C1=CC=C(C(C2=NNN=N2)(C[C@@H](NCC(N3[C@H](C#N)CCC3)=O)C)C4=CC=C(C(N(C)C)=O)C=C4CC5)C5=C1)N(C)C
Biological Activity: AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes[1].
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AMG-222 | AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes. | |||||||||||||||||||||
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