21 Results for "

human granulocytes

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "human granulocytes" in MCE Product Catalog:

Cat. No.: HY-N6013
CAS No.: 8015-61-0
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
loading...
    loading...
Cat. No.: HY-P99440
CAS No.: 2416593-08-1
Synonyms: CSL-324

Target:  

c-Fms JAK STAT

Research Areas:  

Inflammation/Immunology

Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .
loading...
    loading...
Cat. No.: HY-P99232
CAS No.: 1497400-26-6
Synonyms: 5F9 Monoclonal antibody; TAK-164 Antibody
Indusatumab (5F9 Monoclonal antibody) is a monoclonal antibody against human GUCY2C (Guanylate cyclase 2C). Indusatumab fails to bind to granulocytes or erythrocytes. Indusatumab can be used to synthesize ADCs, such as Indusatumab vedotin (HY-P99662). Indusatumab can be used in cancer research .
loading...
    loading...
Cat. No.: HY-P99879
CAS No.: 2200269-79-8
Synonyms: Benegrastim; Bineuta; F 627

Target:  

STAT

Research Areas:  

Inflammation/Immunology

Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .
loading...
    loading...
Cat. No.: HY-P99795
CAS No.: 1638332-55-4
Synonyms: GSK 3196165; MOR103

Target:  

c-Fms

Research Areas:  

Inflammation/Immunology

Otilimab (GSK 3196165) is an anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) human monoclonal antibody. Otilimab neutralises the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor .
loading...
    loading...
Cat. No.: HY-123801
CAS No.: 2187489-08-1
Purity:  98.14%
Synonyms: GL-II-93
Target:  

GABA Receptor

Research Areas:  

Inflammation/Immunology

MIDD0301 (GL-II-93) is an orally available, active γ-aminobutyric acid type A receptor (GABAAR) inhibitor and anti-asthmatic agent. MIDD0301 exhibits biological and immunotoxicological safety in mice and does not affect the number of circulating lymphocytes, monocytes, and granulocytes. MIDD0301 has no significant adverse immune response at repeated doses, which is better than Prednisone (HY-B0214). MIDD0301 relaxes histamine-contracted guinea pig and human airway smooth muscle and is used in the study of bronchoconstrictive diseases .
loading...
    loading...
Cat. No.: HY-P99691
CAS No.: 250242-54-7
Synonyms: IMMU-MN3
Lemalesomab (IMMU-MN3) is a Fab' fragment of a murine anti-granulocyte monoclonal antibody targeting NCA-90 (CEACAM6). Lemalesomab binds strongly to NCA-90 on the surface of granulocytes, cross-reacts with epitopes of other CEA family members, and blocks the binding between human colon adenocarcinoma cells and CEA. When labeled with 99mTc, Lemalesomab can be used for radionuclide imaging of soft tissue infections and osteomyelitis .
loading...
    loading...
Cat. No.: HY-P3981
CAS No.: 134090-73-6
Synonyms: NP-3A; Corticostatin 1, rabbit
Research Areas:  

Neurological Disease

Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity .
loading...
    loading...
Cat. No.: HY-120044
CAS No.: 156511-34-1
Research Areas:  

Cancer

L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro .
loading...
    loading...
Cat. No.: HY-N6013R
CAS No.: 8015-61-0
Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
loading...
    loading...
Cat. No.: HY-P99458
CAS No.: 527698-09-5
Synonyms: CG 10639

Target:  

c-Fms

Research Areas:  

Cancer

Balugrastim (CG 10639) is a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF) obtained by means of a genetic fusion between recombinant human serum albumin and granulocyte colony-stimulating factor. Balugrastim can be used for the research of breast cancer .
loading...
    loading...
Cat. No.: HY-174732
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CSF3 mRNA encodes the human colony stimulating factor 3 (CSF3) protein, a member of the IL-6 superfamily of cytokines. CSF3 controls the production, differentiation, and function of granulocytes.
loading...
    loading...
Cat. No.: HY-174766
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CCL17 mRNA encodes the human C-C motif chemokine ligand 17 (CCL17) protein, a cytokine that displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
loading...
    loading...
Cat. No.: HY-174765
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CCL18 mRNA encodes the human C-C motif chemokine ligand 18 (CCL18) protein, a cytokine that displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. CCL18 may play a role in both humoral and cell-mediated immunity responses.
loading...
    loading...
Cat. No.: HY-155772
CAS No.: 2941609-83-0
LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .
loading...
    loading...
Cat. No.: HY-P990963
CAS No.: 2817686-50-1

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Albipagrastim alfa is a long-acting granulocyte colony-stimulating factor (G-CSF), which is formed by the fusion of highly active recombinant G-CSF and human serum albumin (HSA). Albipagrastim alfa can significantly inhibit the clearance pathway mediated by the G-CSF receptor. Albipagrastim alfa can be used in tumor-related research .
loading...
    loading...
Cat. No.: HY-123801A
CAS No.: 2593569-36-7
Synonyms: GL-II-93 sodium
Target:  

GABA Receptor

Research Areas:  

Inflammation/Immunology

MIDD0301 (GL-II-93) is an orally available, active γ-aminobutyric acid type A receptor (GABAAR) inhibitor and anti-asthmatic agent. MIDD0301 exhibits biological and immunotoxicological safety in mice and does not affect the number of circulating lymphocytes, monocytes, and granulocytes. MIDD0301 has no significant adverse immune response at repeated doses, which is better than Prednisone (HY-B0214). MIDD0301 relaxes histamine-contracted guinea pig and human airway smooth muscle and is used in the study of bronchoconstrictive diseases .
loading...
    loading...
Cat. No.: HY-174743
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CCR5 mRNA encodes the human C-C motif chemokine receptor 5 (CCR5) protein, a member of the beta chemokine receptor family. CCR5 is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. It may also play a role in granulocyte lineage proliferation and differentiation.
loading...
    loading...
Cat. No.: HY-183863
CAS No.: 2868258-17-5
Research Areas:  

Others

N-(4-(1H-Pyrazol-1-yl) butyl)-5-(furan-2-yl) isoxazole-3-carboxamide is a cell culture medium component used for the long-term expansion of granulocyte/macrophage progenitor cells in culture .
loading...
    loading...
Cat. No.: HY-P2158
CAS No.: 84588-89-6
Target:  

Drug Intermediate

Research Areas:  

Cancer

Hemoregulatory peptide 5b is an acidic pentapeptide and also a selective inhibitor of myeloid hematopoiesis. Hemoregulatory peptide 5b inhibits myeloid hematopoietic colony formation, as well as the proliferation of committed myeloid hematopoietic stem cells and differentiating myeloid cells. Hemoregulatory peptide 5b exerts anticancer effects against mouse breast cancer and rat glioma. Hemoregulatory peptide 5b exhibits dose-dependent complex hematopoietic regulatory effects in vivo. Hemoregulatory peptide 5b can be used in research related to breast cancer, glioma, and lymphoma .
loading...
    loading...