Anumigilimab
Based on 1 Customer Validation
Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation.
For research use only. We do not sell to patients.
- Purity: 98.43%
- CAS No.: 2416593-08-1
- Molecular Weight:143.86 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG4 kappa
Human
CSF3R
Anumigilimab (0-100 nM, 48h) inhibits the activation of JAK-1/2 by blocking the binding of G-CSF to G-CSFR, thereby inhibiting the phosphorylation of STAT3 and reducing the proliferation and colony formation of neutrophils[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human neutrophils isolated from human peripheral blood
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Concentration:0-100 nM
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Incubation Time:48 h
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Result:Inhibited cell viability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cynomolgus macaque models[3]
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Dosage:0.1-10 mg/kg
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Administration:iv, single dose
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Result:Controled G-CSF mediated neutrophilia in cynomolgus macaque models without causing neutropenia.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Flow Cytometry analysis of Ramos cells labelling CSF3R (red) with Anumigilimab (anti-CSF3R) (HY-P99440). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG4 (S228P) kappa (HY-P99003). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 2416593-08-1
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Appearance Liquid
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Molecular Weight 143.86 kDa
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Color Colorless to light yellow
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SMILES
[Anumigilimab]
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Synonyms
CSL-324
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Markota Čagalj A, et al. New and Emerging Targeted Therapies for Hidradenitis Suppurativa. Int J Mol Sci. 2022 Mar 29;23(7):3753. [Content Brief]
[2]. Rosales Santillan M, et al. Biologic therapies for the treatment of hidradenitis suppurativa. Expert Opin Biol Ther. 2020 Jun;20(6):621-633. [Content Brief]
[3]. Scalzo-Inguanti K, et al., A neutralizing anti-G-CSFR antibody blocks G-CSF-induced neutrophilia without inducing neutropenia in nonhuman primates. J Leukoc Biol. 2017 Aug;102(2):537-549. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anumigilimab Related Classifications
HY-P99440 Related Classifications
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