84588-89-6
Chemical Structure
Hemoregulatory peptide 5b
- CAS No.: 84588-89-6
- Formula:C23H36N6O11S
- Molecular Weight:604.63
IUPAC Name: ((S)-5-oxopyrrolidine-2-carbonyl)-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine
InChIKey: WMMKLGOAKIPZJN-YTFOTSKYSA-N
SMILES: [C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CS)=O)(NC([C@@H](NC(=O)[C@@H]1CCC(=O)N1)CCC(O)=O)=O)CC(O)=O
Biological Activity: Hemoregulatory peptide 5b is an acidic pentapeptide and also a selective inhibitor of myeloid hematopoiesis. Hemoregulatory peptide 5b inhibits myeloid hematopoietic colony formation, as well as the proliferation of committed myeloid hematopoietic stem cells and differentiating myeloid cells. Hemoregulatory peptide 5b exerts anticancer effects against mouse breast cancer and rat glioma. Hemoregulatory peptide 5b exhibits dose-dependent complex hematopoietic regulatory effects in vivo. Hemoregulatory peptide 5b can be used in research related to breast cancer, glioma, and lymphoma[1][2][3][4].
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Hemoregulatory peptide 5b | Hemoregulatory peptide 5b is an acidic pentapeptide and also a selective inhibitor of myeloid hematopoiesis. Hemoregulatory peptide 5b inhibits myeloid hematopoietic colony formation, as well as the proliferation of committed myeloid hematopoietic stem cells and differentiating myeloid cells. Hemoregulatory peptide 5b exerts anticancer effects against mouse breast cancer and rat glioma. Hemoregulatory peptide 5b exhibits dose-dependent complex hematopoietic regulatory effects in vivo. Hemoregulatory peptide 5b can be used in research related to breast cancer, glioma, and lymphoma. | |||||||||||||||||||||
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- [1]. Laerum OD, et al. Selectivity of hemoregulatory peptide (HP5b) action in culture. International journal of cell cloning. 1990 Nov;8(6):431-44. [Content Brief]
- [2]. Kreja L, et al. Effects of a hemoregulatory peptide (HP5b) on erythroid and myelopoietic colony formation in vitro. Scandinavian journal of haematology. 1986 Aug;37(2):79-86. [Content Brief]
- [3]. Laerum OD, et al. Peripheral blood leukocyte alterations in mice induced by a hemoregulatory pentapeptide (HP 5b). Leuk Res. 1985;9(8):1075-84. [Content Brief]
- [4]. Laerum OD, et al. Modulation of murine hemopoiesis in vivo by a synthetic hemoregulatory pentapeptide (HP 5b). Differentiation. 1984;27(2):106-12. [Content Brief]
Keywords
