Efbemalenograstim alfa
Based on 1 Customer Validation
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells.
For research use only. We do not sell to patients.
- Purity: 97.68%
- CAS No.: 2200269-79-8
- Molecular Weight:89.24 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Efbemalenograstim alfa activates the STAT3 signaling pathway, and promotes the proliferation of 32D-GCSFR and M-NSF60 cells[2].
Efbemalenograstim alfa increases the absolute neutrophil count (ANC) and accelerates the neutrophil recovery, therefore can be used in research of neutropenia[2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[CSF3 (colony stimulating factor 3, GCSF, granulocyte colony-stimulating factor, G-CSF)]2-IGHG2
ELISA, FACS, Functional assay
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Immobilized Efbemalenograstim alfa can bind Human CSF3R/G-CSFR Protein (His Tag). The EC50 for this effect is 7.65 ng/mL.
Chemical Information
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CAS No. 2200269-79-8
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Appearance Liquid
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Molecular Weight 89.24 kDa
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Color Colorless to light yellow
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SMILES
[Efbemalenograstim alfa]
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Synonyms
Benegrastim; Bineuta; F 627
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Efbemalenograstim alfa Related Classifications
HY-P99879 Related Classifications
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