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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
humanized tumor model
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "humanized tumor model" in MCE Product Catalog:
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Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models) .
Cat. No.: HY-P99849
CAS No.: 1471999-69-5
Synonyms: ABT-806
Cat. No.: HY-P99101
CAS No.: 2490556-50-6
Synonyms: AEX-4089; MGC026 antibody
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Cat. No.: HY-P99697
CAS No.: 674782-26-4
Synonyms: PRO 140
Cat. No.: HY-P991558
Synonyms: RG-7356
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Cat. No.: HY-P991584
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ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections .
Cat. No.: HY-P99744
CAS No.: 2254522-19-3
Synonyms: TAK-573
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Cat. No.: HY-P991570
CAS No.: 2378046-35-4
Synonyms: AD5-10; oba-01 Antibody
Cat. No.: HY-P991444
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PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester proagent of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice .
Cat. No.: HY-P99809
CAS No.: 2254059-25-9
Synonyms: MK-1308
Cat. No.: HY-171572
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Atezolizumab-MMAE is an anti-PD-L1 antibody-drug conjugate (ADC) with an EC50 of 1.1 nM. Atezolizumab-MMAE is composed of a humanized anti-PD-L1 antibody (Atezolizumab) (HY-P9904), a lysosomally cleavable dipeptide linker (valine-citrulline), a tubulin inhibitor (MMAE) (HY-15162), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Atezolizumab-MMAE has a potent cytotoxicity (EC50: 9.75-11.94 nM) and immune activation effect. Atezolizumab-MMAE has a significantly anti-tumor activity in MC38 xenograft PD-1-humanized immune system mice model .
Cat. No.: HY-P99712
CAS No.: 2362015-67-4
Synonyms: hz208F2-4
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Cat. No.: HY-P991230
MK-4830 is a fully humanized monoclonal antibody of the immunoglobulin G4 subclass that specifically binds to ILT4 and blocks its interaction with HLA-G and other ligands. MK-4830 inhibits tumor growth in humanized mouse cancer models .
Cat. No.: HY-P991646
Synonyms: heMab
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Cat. No.: HY-P991609
CAS No.: 561063-60-3
Cat. No.: HY-P991561
CAS No.: 2691109-74-5
Cat. No.: HY-P991566
CAS No.: 2983061-18-1
Cat. No.: HY-177414
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BB-1701 is an anti-HER2 antibody-drug conjugate (ADC). BB-1701 consists of a humanized anti-HER2 antibody (Trastuzumab) (HY-P9907), a linker (Mal-PEG2-VCP), and a microtubule inhibitor (Eribulin) (HY-13442), with the drug-linker conjugate of the ADC being Mal-PEG2-VCP-Eribulin (HY-128870). BB-1701 exhibits potent cytotoxicity against various cancer cells, shows a remarkable bystander effect, and induces immunogenic cell death (upregulated cell surface expression of calreticulin, release of ATP/HMGB1, macrophage infiltration) and apoptosis. BB-1701 potently inhibits tumor growth in T-DM1/T-DXd-resistant tumor models. BB-1701 can be used in studies related to breast cancer, gastric cancer, non-small cell lung cancer, and heterogeneous mixed tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
