2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CCR HIV
  4. Leronlimab

Leronlimab  (Synonyms: PRO 140)

Cat. No.: HY-P99697 Purity: 95.00%
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Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.

For research use only. We do not sell to patients.

Leronlimab Chemical Structure

Leronlimab Chemical Structure

CAS No. : 674782-26-4

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Based on 1 publication(s) in Google Scholar

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Description

Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer[1].

In Vitro

Leronlimab (1-140 mg/mL) binds to CCR5-positive cells up to 98%[1].
Leronlimab (80-1750 μg/mL) blocks CCL5, CCL3, and CCL4-induced calcium responses in MDA-MB-231-CCR5 cells[1].
Leronlimab (175 and 350 mg/mL) blocks MDA-MB-231 cell invasion[1].
Leronlimab (10 μg/mL; 72 hours) enhances the cytotoxicity of doxorubicin for MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leronlimab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 cell line
Concentration: 10 μg/mL
Incubation Time: 72 hours
Result: Increased the cells killing effect induced by doxorubicin.
In Vivo

Leronlimab (2 mg; i.p., twice a week) reduces lung metastasis in murine xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection[1]
Dosage: 2 mg
Administration: Intraperitoneal injection; 2 mg, twice a week
Result: Reduced the volume of pulmonary metastases at 8 weeks.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Leronlimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Leronlimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leronlimab674782-26-4PRO 140PRO140PRO-140CCRHIVCC chemokine receptorHuman immunodeficiency virusHIV-1NASHcalciumMDA-MB-231Inhibitorinhibitorinhibit

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