2368182-63-0
2368182-63-0
Chemical Structure
ARB-272572
- CAS No.: 2368182-63-0
- Formula:C32H36N6O4
- Molecular Weight:568.67
IUPAC Name: N,N'-(2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(5-(((2-hydroxyethyl)amino)methyl)picolinamide)
InChIKey: FZEPAZRIEAMJFE-UHFFFAOYSA-N
SMILES: CC1=C(C=CC=C1C2=CC=CC(NC(C3=NC=C(C=C3)CNCCO)=O)=C2C)NC(C4=CC=C(C=N4)CNCCO)=O
Biological Activity: ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ARB-272572 | 99.96% | ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections. | ||||||||||||||||||||
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References
- [1]. Park JJ, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222. [Content Brief]
- [2]. Zhijie Wang, et al. Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway. J Med Chem. 2024 Apr 25;67(8):6027-6043. [Content Brief]
Keywords
