13 Results for "

hypothermic

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "hypothermic" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-N0361
CAS No.: 19408-84-5
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .
loading...
    loading...
Cat. No.: HY-118301
CAS No.: 1207440-88-7
Research Areas:  

Neurological Disease

ADX71441 is an orally active, blood-brain barrier penetrant positive allosteric modulator of GABAB receptor. ADX71441 potentiates the activity of endogenous GABA at GABAB receptor, with an EC50 of 96 nM. ADX71441 functionally inhibits adenosine transporters and 5-HT2B receptor. ADX71441 produces anxiolytic-like, analgesic, muscle relaxant, hypothermic and overactive bladder inhibitory effects, reduces acute locomotor activity levels, decreases voluntary intake of alcohol and saccharin, attenuates stress-induced neuronal activation, and exhibits anti-hyperalgesic activity .
loading...
    loading...
Cat. No.: HY-B0962
CAS No.: 129-77-1
Target:  

mAChR

Research Areas:  

Cardiovascular Disease

Piperidolate hydrochloride is a cholinergic antagonist. Piperidolate hydrochloride prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate hydrochloride causes dose-dependent cardiac depression. Piperidolate hydrochloride can be used for the research of ventricular fibrillation .
loading...
    loading...
Cat. No.: HY-B0962A
CAS No.: 82-98-4
Target:  

mAChR

Research Areas:  

Cardiovascular Disease

Piperidolate is a cholinergic antagonist. Piperidolate prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate causes dose-dependent cardiac depression. Piperidolate can be used for the research of ventricular fibrillation .
loading...
    loading...
Cat. No.: HY-103101
CAS No.: 824958-12-5
Purity:  98.12%
Target:  

5-HT Receptor

Research Areas:  

Others

LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration .
loading...
    loading...
Cat. No.: HY-P1256C
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .
loading...
    loading...
Cat. No.: HY-P3869
CAS No.: 100304-60-7
Synonyms: [D-Arg2]Dermorphin-(1-4) amide
Target:  

Peptides

Research Areas:  

Neurological Disease

Lumekefamide ([D-Arg2]Dermorphin-(1-4) amide) is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. Lumekefamide shows analgesic activity and degradation in soluble mouse liver and brain extracts .
loading...
    loading...
Cat. No.: HY-P1256
CAS No.: 139026-66-7
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [ 125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .
loading...
    loading...
Cat. No.: HY-N0361R
CAS No.: 19408-84-5
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .
loading...
    loading...
Cat. No.: HY-B0962AR
CAS No.: 82-98-4
Research Areas:  

Neurological Disease

Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. Piperidolate is a cholinergic antagonist. Piperidolate prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate causes dose-dependent cardiac depression. Piperidolate can be used for the research of ventricular fibrillation .
loading...
    loading...
Cat. No.: HY-108985
CAS No.: 97110-59-3
Synonyms: EGYT-3615
Target:  

Others

Research Areas:  

Neurological Disease

Trazium esilate (EGYT-3615) is an antidepressant, which influences the central dopaminergic system. Trazium esilate synergizes amphetamine, potentiates stereotypy and hypermotility. Trazium esilate blocks Apomorphine (HY-12723)-induced hypothermic and the stereotypy, and Bulbocapnine (HY-W436270)-induced cataleptic state. Trazium esilate enhances the effect of Norepinephrine (HY-13715) on isolated vas deferens of the rat .
loading...
    loading...
Cat. No.: HY-103101R
CAS No.: 824958-12-5
Research Areas:  

Others

LP44 hydrochloride (Standard) is the analytical standard of LP44 hydrochloride (HY-103101). This product is intended for research and analytical applications. LP44 hydrochloride is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 hydrochloride induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 hydrochloride not causes considerable hypothermic response by intraperitoneal administration .
loading...
    loading...
Cat. No.: HY-P3869A
Synonyms: [D-Arg2]Dermorphin-(1-4) amide TFA
Target:  

Peptides

Research Areas:  

Neurological Disease

Lumekefamide TFA ([D-Arg2]Dermorphin-(1-4) amide TFA) is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. Lumekefamide shows analgesic activity and degradation in soluble mouse liver and brain extracts .
loading...
    loading...
  • 1