97110-59-3
Chemical Structure
Trazium esilate
Synonym(s): EGYT-3615
- CAS No.: 97110-59-3
- Formula:C19H18ClN3O4S
- Molecular Weight:419.88
IUPAC Name: 1-(4-chlorophenyl)-1-hydroxy-1,4-dihydro-[1,2,4]triazino[6,1-a]isoquinolin-5-ium ethanesulfonate
InChIKey: SHXJBCWOVPAZQL-UHFFFAOYSA-M
SMILES: O=S([O-])(CC)=O.ClC1=CC=C(C2(N=CN[N+]3=C2C4=C(C=CC=C4)C=C3)O)C=C1
Biological Activity: Trazium esilate (EGYT-3615) is an antidepressant, which influences the central dopaminergic system. Trazium esilate synergizes amphetamine, potentiates stereotypy and hypermotility. Trazium esilate blocks Apomorphine (HY-12723)-induced hypothermic and the stereotypy, and Bulbocapnine (HY-W436270)-induced cataleptic state. Trazium esilate enhances the effect of Norepinephrine (HY-13715) on isolated vas deferens of the rat[1][2].
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Trazium esilate | Trazium esilate (EGYT-3615) is an antidepressant, which influences the central dopaminergic system. Trazium esilate synergizes amphetamine, potentiates stereotypy and hypermotility. Trazium esilate blocks Apomorphine (HY-12723)-induced hypothermic and the stereotypy, and Bulbocapnine (HY-W436270)-induced cataleptic state. Trazium esilate enhances the effect of Norepinephrine (HY-13715) on isolated vas deferens of the rat. | |||||||||||||||||||||
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References
- [1]. Gyertyán I, et al. Possible involvement of the dopaminergic system in the mode of action of the potential antidepressant trazium esilate. Arzneimittelforschung. 1989 Jul;39(7):775-81. [Content Brief]
- [2]. Gyertyán I, et al., Possible involvement of the dopaminergic system in the mode of action of the potential antidepressant trazium esilate. Arzneimittelforschung. 1989 Jul;39(7):775-81. [Content Brief]
