62 Results for "

indole derivative

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "indole derivative" in MCE Product Catalog:

7
7 Publications Verification
Cat. No.: HY-147216
CAS No.: 3103525-82-9
Purity:  99.77%
Target:  

Lactate Dehydrogenase

Research Areas:  

Cancer

AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC50 value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .
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7
7 Publications Verification
Cat. No.: HY-147216A
Purity:  99.68%
AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .
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2
2 Cited Publications
Cat. No.: HY-W014971
CAS No.: 343-94-2
Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.
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2
2 Cited Publications
Cat. No.: HY-Y0136
CAS No.: 771-51-7
3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .
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2
2 Cited Publications
Cat. No.: HY-33893
CAS No.: 22259-53-6
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .
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1
1 Cited Publications
Cat. No.: HY-111208
CAS No.: 883098-58-6
Purity:  99.71%
Target:  

Phospholipase

Research Areas:  

Cancer

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca 2+ release in squamous carcinoma cells at ~15 μM .
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1
1 Cited Publications
Cat. No.: HY-20897A
CAS No.: 25197-99-3
5-Bromo-L-tryptophan is a substrate of PLP-dependent enzyme AetE, as well as an indole alkaloid and Amino acid derivative. 5-Bromo-L-tryptophan can be isolated from Semenospongia sp. 5-Bromo-L-tryptophan can be converted into 5-bromoindole (HY-30236) via AetE-mediated catalysis. 5-Bromo-L-tryptophan is applicable to colon cancer research .
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1
1 Cited Publications
Cat. No.: HY-32813
CAS No.: 104830-06-0
Synonyms: 3-Iodopyridin-2-amine
2-Amino-3-iodopyridine (3-Iodopyridin-2-amine) can be coupled with formyl derivatives under a copper-catalyzed indole synthesis method, and then constructed azide analogs through copper-mediated conjugated adducts things. The nucleophilicity of 2-Amino-3-iodopyridine is lower than that of the corresponding aniline used in the synthesis of indole, a potential obstacle for future synthesis .
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1
1 Cited Publications
Cat. No.: HY-A0220
CAS No.: 24815-24-5
Synonyms: Reserpinine
Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .
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Cat. No.: HY-W015224
CAS No.: 1912-33-0
Methyl 2-(1H-indol-3-yl)acetate is an indole ester.Methyl 2-(1H-indol-3-yl)acetate serves as a precursor for synthesis of S-alkylated/aralkylated 2-(1H-indol-3-ylmethyl)-1,3,4-oxadiazole-5-thiol derivatives .
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Cat. No.: HY-W015650
CAS No.: 19005-93-7
Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production .
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Cat. No.: HY-W048688
CAS No.: 1334509-86-2
Research Areas:  

Others

Fmoc-Trp(Me)-OH is an amino acid derivative. Fmoc-Trp(Me)-OH is formed by introducing a methyl group onto the nitrogen atom (N-1 position) of the indole ring of tryptophan (Trp) and protecting the amino group with Fmoc (9-fluorenylmethyloxycarbonyl). Fmoc-Trp(Me)-OH can be used in the synthesis of proteins or peptides .
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Cat. No.: HY-W021005
CAS No.: 189114-61-2
Synonyms: Silver triflimide
Silver bis(trifluoromethanesulfonyl)imide is a kind of silver salt and is widely used as an organic synthesis catalyst. Silver bis(trifluoromethanesulfonyl)imide is used for the C-3 regioselective alkylation of indole derivatives with α,β -enones through conjugated addition reactions. Silver bis(trifluoromethanesulfonyl)imide can also be used as a highly efficient and stable solid-state dye sensitization and P-type dopant for perovskite solar cells .
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Cat. No.: HY-W012848
CAS No.: 618-36-0
Synonyms: DL-α-Methylbenzylamine
Target:  

Endogenous Metabolite

Research Areas:  

Neurological Disease Cancer

1-Phenylethanamine is a potential central nervous system stimulant and a related compound of β-phenylethylamine. Due to the replacement of its benzene ring with an indole group, its brain glycogenolytic activity is significantly reduced. Therefore, 1-Phenylethanamine can be used to study the impact of the chemical structure of phenylethylamine derivatives on central nervous system activity. In addition, 1-Phenylethanamine can also be used to synthesize the tyrosine kinase (tyrosine kinase) inhibitor CLM3 (HY-164413) .
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Cat. No.: HY-W588263
CAS No.: 57105-48-3
Synonyms: IAGlu
Target:  

Drug Derivative

Research Areas:  

Others

Indole-3-acetyl glutamate (IAGlu) is a derivative of the plant hormone indole-3-acetic acid (IAA). As a conjugated form of IAA, Indole-3-acetyl glutamate involves in the transport, storage, and homeostatic regulation of IAA within the plant. Indole-3-acetyl glutamate can be used for research into the effects of plant hormones on the growth and development of plants .
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Cat. No.: HY-101647
CAS No.: 125974-72-3
Purity:  98.36%
Synonyms: RP 60475
Target:  

Topoisomerase

Research Areas:  

Cancer

Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 10 5 /M) and thereby increases the length of linear DNA .
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Cat. No.: HY-Y0788
CAS No.: 496-15-1
Indoline is a derivative of Indole (HY-W001132). Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range .
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Cat. No.: HY-169457
CAS No.: 114264-95-8
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

Aeruginascin is an indole derivative and a tryptamine that can be extracted from Inocybe aeruginascens Babos . Aeruginascin may cause an euphoric mood during psychosis with hallucinations .
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Cat. No.: HY-138815
CAS No.: 57105-53-0
Target:  

Glycosidase

Research Areas:  

Metabolic Disease

(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .
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Cat. No.: HY-137884
CAS No.: 608-08-2
Purity:  99.26%
Synonyms: 3-Acetoxyindole
3-Indolyl acetate is an ester derivative of indole that is ubiquitous in various plant tissues, especially in certain cruciferous vegetables such as broccoli and cabbage. 3-Indolyl acetate has unique chemical properties that make it an important signaling molecule in plants, regulating various physiological processes such as growth and defense against pathogens. It also has potential applications in the pharmaceutical industry, as it has been shown to have antitumor and anti-inflammatory effects in some studies.
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