496-15-1
496-15-1
Chemical Structure
Indoline
- CAS No.: 496-15-1
- Formula:C8H9N
- Molecular Weight:119.17
IUPAC Name: indoline
InChIKey: LPAGFVYQRIESJQ-UHFFFAOYSA-N
SMILES: C12=C(NCC2)C=CC=C1
Biological Activity: Indoline is a derivative of Indole (HY-W001132). Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Indoline | 99.89% | Indoline is a derivative of Indole (HY-W001132). Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range. | ||||||||||||||||||||
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Indoline (Standard) | ≥98% | Indoline (Standard) is an analytical standard for Indoline (HY-Y0788). This product is intended for research and analytical applications. Indoline is a HIV-1 envelope glycoprotein gp120 binder. Indoline binds to the conserved CD4-binding site of gp120 (the Phe 43 cavity and its surrounding vestibule), competitively blocks the binding of CD4, and prematurely triggers conformational changes of the Env trimer, resulting in viral inactivation. Indoline induces the conformational opening of HIV-1 Env on infected cells, exposes vulnerable epitopes, increases antibody recognition rate, enhances the binding of FcγRIIIa receptors, and sensitizes infected cells to antibody-dependent cellular cytotoxicity. Indoline is a derivative of Indole (HY-W001132). Indoline can be used in studies related to HIV-1 infection. | ||||||||||||||||||||
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References
Keywords
