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Results for "

kinetochore

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

7

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122236
    UMK57

    		Mitosis Kinesin Microtubule/Tubulin Aurora Kinase Cancer
    UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors .
    UMK57
  • HY-106008
    Avanbulin

    BAL27862

    		 Microtubule/Tubulin Cancer
    Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division .
    Avanbulin
  • HY-150265
    TNH

    TMP-NVOC linker-Halo

    		 Kinesin Others
    TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)) .
    TNH
  • HY-126556
    Cytochalasin J

    		Microtubule/Tubulin Cancer
    Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC50 of 1.5 μM .
    Cytochalasin J
  • HY-123279
    OM137

    		Aurora Kinase CDK Cancer
    OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes .
    OM137
  • HY-W395613
    TY-011

    		Aurora Kinase Cancer
    TY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research .
    TY-011
  • HY-177876
    Cenpemlin

    		Kinesin Others
    Cenpemlin is a CENP-M inhibitor that disrupts the CENP-M/CENP-L interaction. Cenpemlin can be used for investigating centromere-kinetochore interactions and dynamic kinetochore assembly during cell division .
    Cenpemlin
  • HY-165369
    IBPR002

    		Aurora Kinase Cancer
    IBPR002 is an inhibitor of Aurora kinase A and Aurora kinase B, with IC50 values of 41 nM and 17 nM, respectively. IBPR002 disrupts the nucleation and bundling of kinetochore microtubules, impairs the bipolarity of mitotic spindles, and promotes the binding of non-phosphorylated hepatoma up-regulated protein (HURP) to microtubules derived from the mother centrosome. IBPR002 reduces tumorigenesis levels in a colorectal cancer xenograft model using athymic nude mice. IBPR002 is applicable for research related to colorectal cancer .
    IBPR002
  • HY-106008R
    Avanbulin (Standard)

    BAL27862 (Standard)

    		 Reference Standards Microtubule/Tubulin Cancer
    Avanbulin (Standard) is the analytical standard of Avanbulin (HY-106008). This product is intended for research and analytical applications. Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division .
    Avanbulin (Standard)
  • HY-116470
    Mps1/TTK-IN-1

    		Mps1 Cancer
    Mps1/TTK-IN-1 (Compound cpd-5), a derivative of NMS-P715 (HY-12382), is a Mps1 kinase inhibitor with an IC50 of 9.2 nM and a Kd of 1.6 nM. Mps1/TTK-IN-1 specifically targets the ATP-binding pocket of the Mps1 kinase. Mps1/TTK-IN-1 maintains inhibitory activity against Mps1 drug-resistant mutants (C604Y, C604W) with IC50 values of 170 and 19 nM and Kd values of 471 and 349 nM. Mps1/TTK-IN-1 can block the phosphorylation of kinetochore protein KNL1 mediated by Mps1, interfere with the spindle assembly checkpoint function, prevent the correct separation of chromosomes, and thereby inhibit the mitosis and proliferation of tumor cells .
    Mps1/TTK-IN-1

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