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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
kinetochore
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "kinetochore" in MCE Product Catalog:
Research Areas:
UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors .
Synonyms: BAL27862
Target:
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Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division .
Cat. No.: HY-150265
CAS No.: 2137895-00-0
Synonyms: TMP-NVOC linker-Halo
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)) .
Cat. No.: HY-126556
CAS No.: 53760-20-6
Category:
Target:
Cat. No.: HY-123279
CAS No.: 292170-13-9
Target:
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OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes .
Cat. No.: HY-W395613
CAS No.: 1389439-77-3
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TY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research .
Cat. No.: HY-177876
CAS No.: 292031-97-1
Cenpemlin is a CENP-M inhibitor that disrupts the CENP-M/CENP-L interaction. Cenpemlin can be used for investigating centromere-kinetochore interactions and dynamic kinetochore assembly during cell division .
Cat. No.: HY-165369
CAS No.: 1192754-38-3
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IBPR002 is an inhibitor of Aurora kinase A and Aurora kinase B, with IC50 values of 41 nM and 17 nM, respectively. IBPR002 disrupts the nucleation and bundling of kinetochore microtubules, impairs the bipolarity of mitotic spindles, and promotes the binding of non-phosphorylated hepatoma up-regulated protein (HURP) to microtubules derived from the mother centrosome. IBPR002 reduces tumorigenesis levels in a colorectal cancer xenograft model using athymic nude mice. IBPR002 is applicable for research related to colorectal cancer .
Cat. No.: HY-P88314A
Synonyms: centromere protein H; homolog; kinetochore protein CENP-H; MIND kinetochore complex component; NNF1; PMF1
Cat. No.: HY-106008R
CAS No.: 798577-91-0
Synonyms: BAL27862 (Standard)
Research Areas:
Avanbulin (Standard) is the analytical standard of Avanbulin (HY-106008). This product is intended for research and analytical applications. Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division .
Cat. No.: HY-P81416A
Synonyms: CENPF; Centromere protein F; CENP-F; AH antigen; kinetochore protein CENPF; Mitosin
Cat. No.: HY-P71000
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZWINT; Zwint-1; ZW10 Interacting kinetochore Protein; CDNA FLJ36489 Fis, Clone THYMU2018126, Highly Similar To ZW10 Interactor; KNTC2AP; CDNA FLJ60420, Highly Similar To ZW10 Interactor; Zwint1; ZW10 Interactor, kinetochore Protein; SIP30; Human ZW10 Inte
Cat. No.: HY-P71527
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ZWINT; Zwint-1; ZW10 Interacting kinetochore Protein; CDNA FLJ36489 Fis, Clone THYMU2018126, Highly Similar To ZW10 Interactor; KNTC2AP; CDNA FLJ60420, Highly Similar To ZW10 Interactor; Zwint1; ZW10 Interactor, kinetochore Protein; SIP30; Human ZW10 Inte
Cat. No.: HY-116470
CAS No.: 1202055-39-7
Mps1/TTK-IN-1 (Compound cpd-5), a derivative of NMS-P715 (HY-12382), is a Mps1 kinase inhibitor with an IC50 of 9.2 nM and a Kd of 1.6 nM. Mps1/TTK-IN-1 specifically targets the ATP-binding pocket of the Mps1 kinase. Mps1/TTK-IN-1 maintains inhibitory activity against Mps1 drug-resistant mutants (C604Y, C604W) with IC50 values of 170 and 19 nM and Kd values of 471 and 349 nM. Mps1/TTK-IN-1 can block the phosphorylation of kinetochore protein KNL1 mediated by Mps1, interfere with the spindle assembly checkpoint function, prevent the correct separation of chromosomes, and thereby inhibit the mitosis and proliferation of tumor cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
